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Chymase-IN-1

Name: Chymase-IN-1
Brand: TargetMol
SKU: T10811
Price: 157 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10811Cas No. 862090-74-2

Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).

Chymase-IN-1

🥰Excellent

Purity: 99.17%

Catalog No. T10811Cas No. 862090-74-2

Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).

Pack Size	Price	Availability
1 mg	$157	In Stock
5 mg	$388	In Stock
10 mg	$553	In Stock
25 mg	$828	In Stock
50 mg	$1,110	In Stock
100 mg	$1,490	In Stock
500 mg	$2,950	In Stock
1 mL x 10 mM (in DMSO)	$426	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.17%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).
Targets&IC50	Chymase:29 nM
In vitro	Chymase-IN-1 (compound 5f) exhibits a chymase Ki value of 36 nM and a Cat G Ki value of 9500 nM[1].
In vivo	Chymase-IN-1 shows low oral bioavailability in rats (F=3%; oral t1/2=1.8 h)[1].

Chemical Properties

Molecular Weight	431.83
Formula	C₂₀H₁₅ClNO₄PS
Cas No.	862090-74-2
Smiles	C(C(NC1=CC2=C(C=C1)C=CC=C2)=O)(P(=O)(O)O)C=3C=4C(SC3)=CC=C(Cl)C4
Relative Density.	1.583 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (115.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3157 mL	11.5786 mL	23.1573 mL	115.7863 mL
5 mM	0.4631 mL	2.3157 mL	4.6315 mL	23.1573 mL
10 mM	0.2316 mL	1.1579 mL	2.3157 mL	11.5786 mL
20 mM	0.1158 mL	0.5789 mL	1.1579 mL	5.7893 mL
50 mM	0.0463 mL	0.2316 mL	0.4631 mL	2.3157 mL
100 mM	0.0232 mL	0.1158 mL	0.2316 mL	1.1579 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc