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Chymase-IN-1

Name: Chymase-IN-1
Brand: TargetMol
SKU: T10811
Price: 157 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10811Cas No. 862090-74-2

Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).

Chymase-IN-1

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Purity: 99.17%

Catalog No. T10811Cas No. 862090-74-2

Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$157	In Stock	In Stock
5 mg	$388	In Stock	In Stock
10 mg	$553	In Stock	In Stock
25 mg	$828	In Stock	In Stock
50 mg	$1,110	In Stock	In Stock
100 mg	$1,490	In Stock	In Stock
500 mg	$2,950	-	In Stock
1 mL x 10 mM (in DMSO)	$426	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.17%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).
Targets&IC50	Chymase:29 nM
In vitro	Chymase-IN-1 (compound 5f) exhibits a chymase Ki value of 36 nM and a Cat G Ki value of 9500 nM[1].
In vivo	Chymase-IN-1 shows low oral bioavailability in rats (F=3%; oral t1/2=1.8 h)[1].

Chemical Properties

Molecular Weight	431.83
Formula	C₂₀H₁₅ClNO₄PS
Cas No.	862090-74-2
Smiles	C(C(NC1=CC2=C(C=C1)C=CC=C2)=O)(P(=O)(O)O)C=3C=4C(SC3)=CC=C(Cl)C4
Relative Density.	1.583 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (115.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3157 mL	11.5786 mL	23.1573 mL	115.7863 mL
5 mM	0.4631 mL	2.3157 mL	4.6315 mL	23.1573 mL
10 mM	0.2316 mL	1.1579 mL	2.3157 mL	11.5786 mL
20 mM	0.1158 mL	0.5789 mL	1.1579 mL	5.7893 mL
50 mM	0.0463 mL	0.2316 mL	0.4631 mL	2.3157 mL
100 mM	0.0232 mL	0.1158 mL	0.2316 mL	1.1579 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc