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Anti-S100B Antibody (4Y115)
😃Good
Catalog No. TMAY-00414
Alias S100 calcium binding protein B, Bpb, AI850290
Anti-S100B Antibody (4Y115) is a Mouse antibody targeting S100B. Anti-S100B Antibody (4Y115) can be used in IHC-P.
Anti-S100B Antibody (4Y115)
Anti-S100B Antibody (4Y115)
😃Good
Catalog No. TMAY-00414Alias S100 calcium binding protein B, Bpb, AI850290
Anti-S100B Antibody (4Y115) is a Mouse antibody targeting S100B. Anti-S100B Antibody (4Y115) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $69 | 7-10 days | |
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-S100B Antibody (4Y115) is a Mouse antibody targeting S100B. Anti-S100B Antibody (4Y115) can be used in IHC-P. |
| Alias | S100 calcium binding protein B, Bpb, AI850290 |
| Ig Type | Monoclonal Mouse IgG2a |
| Clone | 4Y115 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human S100B in human malignant melanoma with mouse monoclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of human S100B in human lymphoma with mouse monoclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:200-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human S100B (rh S100B; TMPY-02531; NP_006263.1; Ser2-Glu92). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | S100B is a member of the S100 family of proteins containing two EF-hand-type calcium-binding motifs. S100B exerts both intracellular and extracellular functions. Intracellular S100B acts as a stimulator of cell proliferation and migration and an inhibitor of apoptosis and differentiation, which might have important implications during brain, cartilage and skeletal muscle development and repair, activation of astrocytes in the course of brain damage and neurodegenerative processes, and of cardiomyocyte remodeling after infarction, as well as in melanomagenesis and gliomagenesis. As an extracellular factor, S100B engages RAGE (receptor for advanced glycation end products) in a variety of cell types with different outcomes (i.e. beneficial or detrimental, pro-proliferative or pro-differentiative) depending on the concentration attained by the protein, the cell type and the microenvironment. This calcium binding astrocyte-specific cytokine, presents a marker of astrocytic activation and reflects CNS injury. The excellent sensitivity of S100B has enabled it to confirm the existence of subtle brain injury in patients with mild head trauma, strokes, and after successful resuscitation from cardiopulmonary arrest. Recent findings provide evidence, that S100B may decrease neuronal injury and/or contribute to repair following traumatic brain injury (TBI). Hence, S100B, far from being a negative determinant of outcome, as suggested previously in the human TBI and ischemia literature, is of potential therapeutic value that could improve outcome in patients who sustain various forms of acute brain damage. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human S100B Protein (TMPY-02531) |
| Antigen Species | Human |
| Biology Area | Calcium-binding Proteins and Related Molecules |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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