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1-Methylxanthine

🥰Excellent
Catalog No. T10021Cas No. 6136-37-4

1-Methylxanthine is a caffeine derivative. 1-Methylxanthine is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells.

1-Methylxanthine

1-Methylxanthine

🥰Excellent
Purity: 99.11%
Catalog No. T10021Cas No. 6136-37-4
1-Methylxanthine is a caffeine derivative. 1-Methylxanthine is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$30In StockIn Stock
50 mg$41In StockIn Stock
100 mg$56In StockIn Stock
1 mL x 10 mM (in DMSO)$46In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.11%
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Product Introduction

Bioactivity
Description
1-Methylxanthine is a caffeine derivative. 1-Methylxanthine is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells.
In vitro
1-Methylxanthine exhibits similar activities to other naturally occurring methylxanthines. Unlike caffeine and theobromine, 3-Methylxanthine, and 1-methylxanthine do not occur naturally at high levels in plants. 1-Methylxanthine (3 mM; for 30 min) increases the radiation-induced clonogenic and apoptotic cell (RKO human colorectal cancer cells carrying wild type protein 53 kDa (p53)) death.
Chemical Properties
Molecular Weight166.14
FormulaC6H6N4O2
Cas No.6136-37-4
SmilesCN1C(=O)NC2=C(NC=N2)C1=O
Relative Density.1.539 g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 20 mg/mL (120.38 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (6.02 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM6.0190 mL30.0951 mL60.1902 mL300.9510 mL
5 mM1.2038 mL6.0190 mL12.0380 mL60.1902 mL
10 mM0.6019 mL3.0095 mL6.0190 mL30.0951 mL
20 mM0.3010 mL1.5048 mL3.0095 mL15.0476 mL
50 mM0.1204 mL0.6019 mL1.2038 mL6.0190 mL
100 mM0.0602 mL0.3010 mL0.6019 mL3.0095 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

urinarytumortheophyllinemetaboliteInhibitorinhibitHuman Endogenous MetabolitehumanEndogenousMetaboliteEndogenous Metabolitecaffeine1-Methylxanthine1Methylxanthine1 Methylxanthine
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