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Cystamine

Name: Cystamine
Brand: TargetMol
SKU: T15035
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15035Cas No. 51-85-4

Alias 2,2'-Disulfanediyldiethanamine

Cystamine (2,2'-Disulfanediyldiethanamine) is an inhibitor of transglutaminase and inhibits caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used in studies about Huntington's diseases.

Cystamine

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Purity: 99.41%

Catalog No. T15035Alias 2,2'-DisulfanediyldiethanamineCas No. 51-85-4

Cystamine (2,2'-Disulfanediyldiethanamine) is an inhibitor of transglutaminase and inhibits caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used in studies about Huntington's diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$34	In Stock	In Stock
50 mg	$48	In Stock	In Stock
100 mg	$73	In Stock	In Stock
500 mg	$228	-	In Stock
1 mL x 10 mM (in DMSO)	$39	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.41%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Cystamine (2,2'-Disulfanediyldiethanamine) is an inhibitor of transglutaminase and inhibits caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used in studies about Huntington's diseases.
Targets&IC50	Caspase-3:23.6 μM
In vitro	In human neuroblastoma SH-SY5Y cells, Cystamine inhibits the MG132-mediated and H2O2-mediated activation of caspase-3 in a concentration-dependent manner. Cystamine (250 μM) robustly results in an increasement of the glutathione level[1].
In vivo	In R6/2 transgenic HD mice, oral and intraperitoneal administration of Cystamine (112-225 mg/kg) reduces the levels of transglutaminase and N(Sigma)-(gamma-L-glutamyl)-L-lysin. Cystamine extends survival and improves body weight and motor performance[2].
Synonyms	2,2'-Disulfanediyldiethanamine

Chemical Properties

Molecular Weight	152.28
Formula	C₄H₁₂N₂S₂
Cas No.	51-85-4
Smiles	NCCSSCCN
Relative Density.	1.172g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (591.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (21.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.5669 mL	32.8343 mL	65.6685 mL	328.3425 mL
5 mM	1.3134 mL	6.5669 mL	13.1337 mL	65.6685 mL
10 mM	0.6567 mL	3.2834 mL	6.5669 mL	32.8343 mL
20 mM	0.3283 mL	1.6417 mL	3.2834 mL	16.4171 mL
50 mM	0.1313 mL	0.6567 mL	1.3134 mL	6.5669 mL
100 mM	0.0657 mL	0.3283 mL	0.6567 mL	3.2834 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc