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DLin-KC2-DMA

Name: DLin-KC2-DMA
Brand: TargetMol
SKU: T15139
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15139Cas No. 1190197-97-7

DLin-KC2-DMA is a cation that can be used for siRNA delivery and is also an ionizable lipid. DLinKC2-DMA can bind to LNP and enable siRNA-mediated GAPDH gene silencing.

DLin-KC2-DMA

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Purity: 98.60%

Catalog No. T15139Cas No. 1190197-97-7

DLin-KC2-DMA is a cation that can be used for siRNA delivery and is also an ionizable lipid. DLinKC2-DMA can bind to LNP and enable siRNA-mediated GAPDH gene silencing.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	-	In Stock
5 mg	$76	In Stock	In Stock
10 mg	$123	In Stock	In Stock
25 mg	$248	-	In Stock
50 mg	$353	-	In Stock
100 mg	$523	-	In Stock
200 mg	$747	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.60%

Color:Transparent to Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	DLin-KC2-DMA is a cation that can be used for siRNA delivery and is also an ionizable lipid. DLinKC2-DMA can bind to LNP and enable siRNA-mediated GAPDH gene silencing.
In vitro	METHODS: Macrophages (MΦ) and dendritic cells (DC) were treated with DLinKC2-DMA (1,5μg/mL) to observe the effect of DLinKC2-DMA on siRNA-mediated gene silencing. GAPDH and control α-tubulin expression were evaluated using Western blot analysis and flow cytometry. RESULTS At a dose level of 5μg/ml, LNPs containing DLinKC2-DMA were again the most effective gene silencing agents. [1]
In vivo	METHODS: C57Bl6 mice were injected with DLinKC2-DMA-formulated LNP siRNA (5 mg/kg, tail vein injection) via the tail vein to study the in vivo gene silencing properties of DLinKC2-DMA-formulated LNP siRNA. RESULTS DLinKC2-DMA effectively silenced target genes in APcs in vivo. [1]

Chemical Properties

Molecular Weight	642.09
Formula	C₄₃H₇₉NO₂
Cas No.	1190197-97-7
Smiles	CCCCC\C=C/C\C=C/CCCCCCCCC1(CCCCCCCC\C=C/C\C=C/CCCCC)OCC(CCN(C)C)O1
Relative Density.	0.885 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years

Solubility Information

Ethanol: 50 mg/mL (77.87 mM), Sonication is recommended.

DMSO: 100 mg/mL (155.74 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5574 mL	7.7871 mL	15.5741 mL	77.8707 mL
5 mM	0.3115 mL	1.5574 mL	3.1148 mL	15.5741 mL
10 mM	0.1557 mL	0.7787 mL	1.5574 mL	7.7871 mL
20 mM	0.0779 mL	0.3894 mL	0.7787 mL	3.8935 mL
50 mM	0.0311 mL	0.1557 mL	0.3115 mL	1.5574 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0156 mL	0.0779 mL	0.1557 mL	0.7787 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc