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DLin-KC2-DMA
🥰Excellent
Catalog No. T15139Cas No. 1190197-97-7
DLin-KC2-DMA is a cation that can be used for siRNA delivery and is also an ionizable lipid. DLinKC2-DMA can bind to LNP and enable siRNA-mediated GAPDH gene silencing.
DLin-KC2-DMA
🥰Excellent
Purity: 97.74%
Catalog No. T15139Cas No. 1190197-97-7
DLin-KC2-DMA is a cation that can be used for siRNA delivery and is also an ionizable lipid. DLinKC2-DMA can bind to LNP and enable siRNA-mediated GAPDH gene silencing.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $33 | - | In Stock | |
| 5 mg | $76 | In Stock | In Stock | |
| 10 mg | $123 | In Stock | In Stock | |
| 25 mg | $248 | - | In Stock | |
| 50 mg | $353 | - | In Stock | |
| 100 mg | $523 | - | In Stock | |
| 200 mg | $747 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:97.74%
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Product Introduction
Bioactivity
Chemical Properties
| Description | DLin-KC2-DMA is a cation that can be used for siRNA delivery and is also an ionizable lipid. DLinKC2-DMA can bind to LNP and enable siRNA-mediated GAPDH gene silencing. |
| In vitro | METHODS: Macrophages (MΦ) and dendritic cells (DC) were treated with DLinKC2-DMA (1,5μg/mL) to observe the effect of DLinKC2-DMA on siRNA-mediated gene silencing. GAPDH and control α-tubulin expression were evaluated using Western blot analysis and flow cytometry. RESULTS At a dose level of 5μg/ml, LNPs containing DLinKC2-DMA were again the most effective gene silencing agents. [1] |
| In vivo | METHODS: C57Bl6 mice were injected with DLinKC2-DMA-formulated LNP siRNA (5 mg/kg, tail vein injection) via the tail vein to study the in vivo gene silencing properties of DLinKC2-DMA-formulated LNP siRNA. RESULTS DLinKC2-DMA effectively silenced target genes in APcs in vivo. [1] |
| Molecular Weight | 642.09 |
| Formula | C43H79NO2 |
| Cas No. | 1190197-97-7 |
| Smiles | CCCCC\C=C/C\C=C/CCCCCCCCC1(CCCCCCCC\C=C/C\C=C/CCCCC)OCC(CCN(C)C)O1 |
| Relative Density. | 0.885 g/cm3 (Predicted) |
| Color | Yellow |
| Appearance | Liquid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 50 mg/mL (77.87 mM), Sonication is recommended. DMSO: 100 mg/mL (155.74 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.23 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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