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Ro 10-5824 dihydrochloride

Name: Ro 10-5824 dihydrochloride
Brand: TargetMol
SKU: T12761
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12761Cas No. 189744-94-3

Ro 10-5824 dihydrochloride is a selective partial agonist of the dopamine D4 receptor, with a Ki of 5.2 nM.

Ro 10-5824 dihydrochloride

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Purity: 99.79%

Catalog No. T12761Cas No. 189744-94-3

Ro 10-5824 dihydrochloride is a selective partial agonist of the dopamine D4 receptor, with a Ki of 5.2 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$29	In Stock	In Stock
10 mg	$46	In Stock	In Stock
25 mg	$78	In Stock	In Stock
50 mg	$127	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.79%

Appearance:Solid

Color:White

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COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Ro 10-5824 dihydrochloride is a selective partial agonist of the dopamine D4 receptor, with a Ki of 5.2 nM.
Targets&IC50	D4 receptor:5.2 nM (ki)
In vitro	RO-10-5824 exhibits high affinity binding (Ki=5.2±0.9 nM (n=3)), 250-fold selectivity over human D3R, and >1000-fold selectivity for D4 versus human D2, D1, and D5 receptors. It stimulates 35S-GTPγS binding (EC50: 205±67 nM) (n=7) with a maximal induction of 36±4% above basal level [2].
In vivo	The success rate in the ORD task increased by Ro 10-5824 (3 mg/kg). At doses of 1 and 3 mg/kg, in the frontal cortex, Ro 10-5824 increases baseline gamma band activity. RO-10-5824 (10.0 mg/kg) does not increase center entries in the open field in a single 60-min session without the novel object present, nor does it increase overall transitions in the initial experiment with C57 mice[2].

Chemical Properties

Molecular Weight	353.29
Formula	C₁₇H₂₂Cl₂N₄
Cas No.	189744-94-3
Smiles	Cl.Cl.Cc1ncc(CN2CCC(=CC2)c2ccccc2)c(N)n1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 60 mg/mL (169.83 mM), Sonication is recommended.

DMSO: 8.33 mg/mL (23.58 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.8305 mL	14.1527 mL	28.3054 mL	141.5268 mL
5 mM	0.5661 mL	2.8305 mL	5.6611 mL	28.3054 mL
10 mM	0.2831 mL	1.4153 mL	2.8305 mL	14.1527 mL
20 mM	0.1415 mL	0.7076 mL	1.4153 mL	7.0763 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0566 mL	0.2831 mL	0.5661 mL	2.8305 mL
100 mM	0.0283 mL	0.1415 mL	0.2831 mL	1.4153 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc