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N-Chloroacetyl-3,5-bis(trifluoromethyl)aniline
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Catalog No. T9269Cas No. 790-75-0
Alias N-(3,5-Bis(trifluoromethyl)phenyl)-2-chloroacetamide
N-Chloroacetyl-3,5-bis(trifluoromethyl)aniline (KM1954) is an insecticide, it is most active against 1st stage Ae. aegypti larvae with LC50 values of 125μM.
N-Chloroacetyl-3,5-bis(trifluoromethyl)aniline
Copy Product Info🥰Excellent
Purity: 98.1%
Catalog No. T9269Alias N-(3,5-Bis(trifluoromethyl)phenyl)-2-chloroacetamideCas No. 790-75-0
N-Chloroacetyl-3,5-bis(trifluoromethyl)aniline (KM1954) is an insecticide, it is most active against 1st stage Ae. aegypti larvae with LC50 values of 125μM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 mg | $29 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.1%
Appearance:Solid
Color:Yellow
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Product Introduction
N-Chloroacetyl-3,5-bis(trifluoromethyl)aniline AI Summary
N-Chloroacetyl-3,5-bis(trifluoromethyl)aniline exhibits significant drug reactivity against various sulfur-containing compounds such as cysteamine, cysteine, and glutathione, with varying half-lives indicating different interaction strengths. Notably, it has longer half-lives with N-acetyl-cysteine, N-benzoyl-cysteine, and glutathione, suggesting potentially stronger interactions, while its reactivity with N-benzoyl-glutathione is very slow (half-life > 50 hours). The compound inhibits Escherichia coli and Staphylococcus aureus MurA enzymes (IC50 values of 75,000 nM and 100,000 nM respectively) and affects the activities of recombinant cathepsin B and X enzymes with inhibition ranging from 75% to 100% at a 100 µM concentration.
In terms of reactivity, compound 2485811 has a thiol reactivity rate constant of 0.12 /hr and a half-life of 5.8 hours in pH 7.4 PBS buffer, alongside good aqueous stability with a degradation kinetic constant of 0.004 /hr and a half-life exceeding 72 hours. It also demonstrates varied inhibition of several kinases, such as BTK (81%), ERK2 (7%), RSK2 (14%), MAP2K4 (55%), JAK3 (97%), and MELK (36%) when preincubated at 100 µM for 1 hour and measured after substrate addition. Furthermore, the compound maintains drug metabolism stability of 72% over 24 hours..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | N-Chloroacetyl-3,5-bis(trifluoromethyl)aniline (KM1954) is an insecticide, it is most active against 1st stage Ae. aegypti larvae with LC50 values of 125μM. |
| Synonyms | N-(3,5-Bis(trifluoromethyl)phenyl)-2-chloroacetamide |
| Molecular Weight | 305.6 |
| Formula | C10H6ClF6NO |
| Cas No. | 790-75-0 |
| Smiles | FC(F)(F)C1=CC(=CC(NC(=O)CCl)=C1)C(F)(F)F |
| Relative Density. | 1.52g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 65 mg/mL (212.7 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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