This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Prolactin Releasing Peptide (1-31), human acetate
Catalog No. T78006
Prolactin Releasing Peptide (1-31), human (acetate), is a potent GPR10 ligand with high affinity, eliciting prolactin secretion. It binds to human and rat GPR10 with K_i values of 1.03 nM and 0.33 nM, respectively, and serves as a tool for researching the hypothalamo-pituitary axis [1] [2].
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Prolactin Releasing Peptide (1-31), human acetate, CAS N/A
Prolactin Releasing Peptide (1-31), human (acetate), is a potent GPR10 ligand with high affinity, eliciting prolactin secretion. It binds to human and rat GPR10 with K_i values of 1.03 nM and 0.33 nM, respectively, and serves as a tool for researching the hypothalamo-pituitary axis [1] [2].
In vitro
Prolactin Releasing Peptide (1-31), human (acetate), exhibits high affinity for the GPR10 receptor in both humans and rats, with Ki values of 1.03 nM and 0.33 nM, respectively [1].
In vivo
Prolactin Releasing Peptide (1-31), human (acetate) administered intracerebroventricularly (ICV) at 5 nM enhances plasma follicle-stimulating hormone (FSH), elevates total plasma testosterone levels, and significantly augments luteinizing hormone-releasing hormone (LHRH) release from in vitro hypothalamic explants [2]. At a higher concentration of 100 nM ICV, the peptide also upregulates hypothalamic peptides that regulate pituitary hormone secretion, specifically vasoactive intestinal peptide (VIP) and galanin, while not affecting orexin A secretion [2].
Molecular Weight
3724.17
Formula
C162H26N56O44S
Storage
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
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Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.