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DL-Sulforaphane N-acetyl-L-cysteine

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Catalog No. T36614Cas No. 334829-66-2
Alias SFN-NAC, SFNNAC

DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), a metabolite of sulforaphane, induces apoptosis through down-regulation of α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and up-regulation of Hsp70 through phosphorylation of ERK1/2 in non-small-cell lung cancer (NSCLC).

DL-Sulforaphane N-acetyl-L-cysteine

DL-Sulforaphane N-acetyl-L-cysteine

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Purity: 99%
Catalog No. T36614Alias SFN-NAC, SFNNACCas No. 334829-66-2
DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), a metabolite of sulforaphane, induces apoptosis through down-regulation of α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and up-regulation of Hsp70 through phosphorylation of ERK1/2 in non-small-cell lung cancer (NSCLC).
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1 mg$199-In Stock
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Purity:99%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), a metabolite of sulforaphane, induces apoptosis through down-regulation of α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and up-regulation of Hsp70 through phosphorylation of ERK1/2 in non-small-cell lung cancer (NSCLC).
Targets&IC50
U-87MG cells:35.20 μM, HA cells:60.08 μM, U-373MG cells:39.11 μM
In vitro
In studies on U87MG and U373MG cells, treatment with DL-Sulforaphane N-acetyl-L-cysteine (30 μM) for 24 hours resulted in cell cycle analysis showing drug-induced G2/M phase arrest, along with the initiation of apoptosis. In the same cell lines, Western blot analysis revealed that DL-Sulforaphane N-acetyl-L-cysteine, within a concentration range of 10 to 50 μM, activated ERK1/2 (Thr202/Tyr204), downregulated α-tubulin, and induced autophagy in a dose-dependent manner. Additionally, cell viability assays showed that DL-Sulforaphane N-acetyl-L-cysteine, within a concentration range of 0 to 90 μM, decreased the viability of HA cells, U87MG cells, and U373MG cells in a dose-dependent manner, with IC50 values of 60.08 μM, 35.20 μM, and 39.11 μM, respectively[1].
In vivo
In the HDAC inhibition model, DL-Sulforaphane N-acetyl-L-cysteine (10 μmol, oral gavage, single dose, 6-hour treatment) significantly inhibited histone deacetylase (HDAC) activity in the colon mucosa of mice[2].
SynonymsSFN-NAC, SFNNAC
Chemical Properties
Molecular Weight340.48
FormulaC11H20N2O4S3
Cas No.334829-66-2
Smiles[C@@H](CSC(NCCCCS(C)=O)=S)(NC(C)=O)C(O)=O
Relative Density.1.371 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 8 mg/mL (23.5 mM), Sonication is recommended.
PBS (pH 7.2): 8 mg/mL (23.5 mM), Sonication is recommended.
Ethanol: 4 mg/mL (11.75 mM), Sonication is recommended.
DMF: 8 mg/mL (23.5 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO/PBS (pH 7.2)/DMF
1mg5mg10mg50mg
1 mM2.9370 mL14.6852 mL29.3703 mL146.8515 mL
5 mM0.5874 mL2.9370 mL5.8741 mL29.3703 mL
10 mM0.2937 mL1.4685 mL2.9370 mL14.6852 mL
DMSO/PBS (pH 7.2)/DMF
1mg5mg10mg50mg
20 mM0.1469 mL0.7343 mL1.4685 mL7.3426 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

DL-Sulforaphane N-acetyl-L-cysteineDLSulforaphane NacetylLcysteineDL Sulforaphane N acetyl L cysteine
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