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DL-Sulforaphane N-acetyl-L-cysteine
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Catalog No. T36614Cas No. 334829-66-2
Alias SFN-NAC, SFNNAC
DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), a metabolite of sulforaphane, induces apoptosis through down-regulation of α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and up-regulation of Hsp70 through phosphorylation of ERK1/2 in non-small-cell lung cancer (NSCLC).
DL-Sulforaphane N-acetyl-L-cysteine
😃Good
Catalog No. T36614Alias SFN-NAC, SFNNACCas No. 334829-66-2
DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), a metabolite of sulforaphane, induces apoptosis through down-regulation of α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and up-regulation of Hsp70 through phosphorylation of ERK1/2 in non-small-cell lung cancer (NSCLC).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $110 | In Stock | |
| 5 mg | $483 | 35 days | |
| 10 mg | $853 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), a metabolite of sulforaphane, induces apoptosis through down-regulation of α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and up-regulation of Hsp70 through phosphorylation of ERK1/2 in non-small-cell lung cancer (NSCLC). |
| Targets&IC50 | U373MG cells:39.11 μM, U87MG cells:35.20 μM, HA cells:60.08 μM |
| In vitro | In studies on U87MG and U373MG cells, treatment with DL-Sulforaphane N-acetyl-L-cysteine (30 μM) for 24 hours resulted in cell cycle analysis showing drug-induced G2/M phase arrest, along with the initiation of apoptosis. In the same cell lines, Western blot analysis revealed that DL-Sulforaphane N-acetyl-L-cysteine, within a concentration range of 10 to 50 μM, activated ERK1/2 (Thr202/Tyr204), downregulated α-tubulin, and induced autophagy in a dose-dependent manner. Additionally, cell viability assays showed that DL-Sulforaphane N-acetyl-L-cysteine, within a concentration range of 0 to 90 μM, decreased the viability of HA cells, U87MG cells, and U373MG cells in a dose-dependent manner, with IC50 values of 60.08 μM, 35.20 μM, and 39.11 μM, respectively[1]. |
| In vivo | In the HDAC inhibition model, DL-Sulforaphane N-acetyl-L-cysteine (10 μmol, oral gavage, single dose, 6-hour treatment) significantly inhibited histone deacetylase (HDAC) activity in the colon mucosa of mice[2]. |
| Alias | SFN-NAC, SFNNAC |
| Molecular Weight | 340.48 |
| Formula | C11H20N2O4S3 |
| Cas No. | 334829-66-2 |
| Smiles | [C@@H](CSC(NCCCCS(C)=O)=S)(NC(C)=O)C(O)=O |
| Relative Density. | 1.371 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 8.00 mg/mL (23.50 mM), Sonication is recommended. PBS (pH 7.2): 8.00 mg/mL (23.50 mM), Sonication is recommended. Ethanol: 4.00 mg/mL (11.75 mM), Sonication is recommended. DMF: 8.00 mg/mL (23.50 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
Ethanol/DMSO/PBS (pH 7.2)/DMF
DMSO/PBS (pH 7.2)/DMF
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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