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Orphenadrine Citrate

Name: Orphenadrine Citrate
Brand: TargetMol
SKU: T6618
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6618Cas No. 4682-36-4

Alias Flexon, Flexoject, Banflex

Orphenadrine Citrate (Flexon) is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.

Orphenadrine Citrate

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Purity: 99.58%

Catalog No. T6618Alias Flexon, Flexoject, BanflexCas No. 4682-36-4

Orphenadrine Citrate (Flexon) is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$31	In Stock	In Stock
200 mg	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.58%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Orphenadrine Citrate AI Summary

Orphenadrine Citrate demonstrates a diverse range of bioactivities affecting multiple biological targets and processes. It induces DNA re-replication in SW480 colon adenocarcinoma cells, inhibits tyrosyl-DNA phosphodiesterase 1, and exhibits activity against Hepatitis C Virus, Marburg Virus, and Ebola Virus by blocking their binding or entry into cells. Additionally, it influences insulin secretion in INS-1E cells and affects enzymes like AMPase and Histone Lysine Methyltransferase which are involved in DNA function and cell cycle regulation. The compound significantly inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells at 10 µM, showing 96.44% and 87.55% inhibition respectively. It also acts as an inhibitor of the SARS-CoV-2 3CL-Pro protease, with 7.93% inhibition at 20 µM, and reduces SARS-CoV-2 induced cytotoxicity in VERO-6 cells by 0.03% at 10 µM after 48 hours. Overall, Orphenadrine Citrate exhibits significant bioactivity across various cellular and viral targets..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Orphenadrine Citrate (Flexon) is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
Targets&IC50	ONMDA:6.0 +/- 0.7 μM(Ki)
Synonyms	Flexon, Flexoject, Banflex

Chemical Properties

Molecular Weight	461.5
Formula	C₁₈H₂₃NO·C₆H₈O₇
Cas No.	4682-36-4
Smiles	OC(=O)CC(O)(CC(O)=O)C(O)=O.CN(C)CCOC(c1ccccc1)c1ccccc1C
Relative Density.	1.014 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 85 mg/mL (184.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1668 mL	10.8342 mL	21.6685 mL	108.3424 mL
5 mM	0.4334 mL	2.1668 mL	4.3337 mL	21.6685 mL
10 mM	0.2167 mL	1.0834 mL	2.1668 mL	10.8342 mL
20 mM	0.1083 mL	0.5417 mL	1.0834 mL	5.4171 mL
50 mM	0.0433 mL	0.2167 mL	0.4334 mL	2.1668 mL
100 mM	0.0217 mL	0.1083 mL	0.2167 mL	1.0834 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc