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PFI-3

Name: PFI-3
Brand: TargetMol
SKU: T6939
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6939Cas No. 1819363-80-8

Alias PFI 3

PFI-3 is a selective chemical inhibitor for SMARCA (2/4) (Kd = 89 nM)and PBI (5) bromodomains which may result in the delay and prevention of breast cancer.

PFI-3

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Purity: 99.94%

Catalog No. T6939Alias PFI 3Cas No. 1819363-80-8

PFI-3 is a selective chemical inhibitor for SMARCA (2/4) (Kd = 89 nM)and PBI (5) bromodomains which may result in the delay and prevention of breast cancer.

Pack Size	Price	Availability
1 mg	$32	In Stock
2 mg	$45	In Stock
5 mg	$71	In Stock
10 mg	$105	In Stock
25 mg	$220	In Stock
50 mg	$335	In Stock
100 mg	$498	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock

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Batch Information

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Purity:99.94%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	PFI-3 is a selective chemical inhibitor for SMARCA (2/4) (Kd = 89 nM)and PBI (5) bromodomains which may result in the delay and prevention of breast cancer.
Targets&IC50	SMARCA4:55 nM(Kd), SMARCA2A:110 nM(Kd), SMARCA2B:72 nM(Kd)
In vitro	PFI-3 shows a significant selectivity for PB1(5) and SMARCA2/4 over 36 other tested kinases. [1]
Synonyms	PFI 3

Chemical Properties

Molecular Weight	321.37
Formula	C₁₉H₁₉N₃O₂
Cas No.	1819363-80-8
Smiles	[H][C@@]12CN(c3ccccn3)[C@@]([H])(CN1\C=C\C(=O)c1ccccc1O)C2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 32.1 mg/mL (99.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1117 mL	15.5584 mL	31.1168 mL	155.5839 mL
5 mM	0.6223 mL	3.1117 mL	6.2234 mL	31.1168 mL
10 mM	0.3112 mL	1.5558 mL	3.1117 mL	15.5584 mL
20 mM	0.1556 mL	0.7779 mL	1.5558 mL	7.7792 mL
50 mM	0.0622 mL	0.3112 mL	0.6223 mL	3.1117 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc