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Clofibric acid

Name: Clofibric acid
Brand: TargetMol
SKU: T0061
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0061Cas No. 882-09-7

Alias Chlorofibrinic acid

Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.

Clofibric acid

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Purity: 99.8%

Catalog No. T0061Alias Chlorofibrinic acidCas No. 882-09-7

Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.

Pack Size	Price	Availability
2 g	$30	In Stock
5 g	$43	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.8%

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COA HPLC

Product Introduction

Bioactivity

Description	Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
In vitro	Clofibric acid enhances the expression of carbonyl reductase in vivo, reduces PGE2 levels, and diminishes the quantity of vascular endothelial growth factor (VEGF) in OVCAR-3 tumors and DISS-origin ascites. In solid OVCAR-3 tumors, it decreases microvascular density and induces apoptosis. Compared to the control, a 9,000 ppm Clofibric acid diet significantly reduces the growth of OVCAR-3 tumor xenografts s.c. by 46% and notably prolongs the survival of mice with DISS-origin malignant ascites.
In vivo	Clofibric acid enhances the expression of the CYP4A6 gene in RK13 cells transfected with PPAR-Gamma.
Synonyms	Chlorofibrinic acid

Chemical Properties

Molecular Weight	214.65
Formula	C₁₀H₁₁ClO₃
Cas No.	882-09-7
Smiles	CC(C)(OC1=CC=C(Cl)C=C1)C(O)=O
Relative Density.	1.265 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 40 mg/mL (186.35 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 45 mg/mL (209.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6587 mL	23.2937 mL	46.5875 mL	232.9373 mL
5 mM	0.9317 mL	4.6587 mL	9.3175 mL	46.5875 mL
10 mM	0.4659 mL	2.3294 mL	4.6587 mL	23.2937 mL
20 mM	0.2329 mL	1.1647 mL	2.3294 mL	11.6469 mL
50 mM	0.0932 mL	0.4659 mL	0.9317 mL	4.6587 mL
100 mM	0.0466 mL	0.2329 mL	0.4659 mL	2.3294 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc