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Anti-MMP-2 Antibody (8P581)
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Catalog No. TMAY-00230
Alias MMP-2, matrix metallopeptidase 2, GelA, Clg4a
Anti-MMP-2 Antibody (8P581) is a Rabbit antibody targeting MMP-2. Anti-MMP-2 Antibody (8P581) can be used in WB.
Anti-MMP-2 Antibody (8P581)
Anti-MMP-2 Antibody (8P581)
😃Good
Catalog No. TMAY-00230Alias MMP-2, matrix metallopeptidase 2, GelA, Clg4a
Anti-MMP-2 Antibody (8P581) is a Rabbit antibody targeting MMP-2. Anti-MMP-2 Antibody (8P581) can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | 256 € | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-MMP-2 Antibody (8P581) is a Rabbit antibody targeting MMP-2. Anti-MMP-2 Antibody (8P581) can be used in WB. |
| Alias | MMP-2, matrix metallopeptidase 2, GelA, Clg4a |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 8P581 |
| Reactivity | Human |
| Verified Activity | Anti-MMP2 rabbit monoclonal antibody at 1:500 dilution. -Lane A: MCF7 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:73 kDa. -Observed band size:73 kDa |
| Application | WB |
| Recommended Dose | WB: 1:500-1:1000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human MMP-2 (rh MMP-2; TMPY-01477; NP_004521.1; Met 1-Cys660). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to a favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human MMP-2 protein (TMPY-01477) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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