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Naproxcinod
🥰Excellent
Catalog No. T33595Cas No. 163133-43-5
Alias Nitronaproxen, Naproxen-N-butyl nitrate, HCT-3012, HCT3012, AZD3582, AZD 3582
Naproxcinod is a derivative of naproxen exhibiting analgesic and anti-inflammatory activity. As a cyclooxygenase (COX)-inhibitory nitric oxide donor (CINOD), it is indicated for osteoarthritis and inflammatory conditions.
Naproxcinod
🥰Excellent
Purity: 99.85%
Catalog No. T33595Alias Nitronaproxen, Naproxen-N-butyl nitrate, HCT-3012, HCT3012, AZD3582, AZD 3582Cas No. 163133-43-5
Naproxcinod is a derivative of naproxen exhibiting analgesic and anti-inflammatory activity. As a cyclooxygenase (COX)-inhibitory nitric oxide donor (CINOD), it is indicated for osteoarthritis and inflammatory conditions.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $293 | - | In Stock | |
| 5 mg | $722 | - | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,520 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock | |
| 100 mg | $2,500 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.85%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Naproxcinod is a derivative of naproxen exhibiting analgesic and anti-inflammatory activity. As a cyclooxygenase (COX)-inhibitory nitric oxide donor (CINOD), it is indicated for osteoarthritis and inflammatory conditions. |
| In vitro | Naproxcinod (1-30 μM, 15 minutes) increased cGMP levels in a concentration-dependent manner, reaching up to 27 times the baseline level [1]. Naproxcinod (1-100 μM, 8 hours) enhanced HO-1 mRNA expression in endothelial cells in a concentration-dependent manner [2]. |
| In vivo | Naproxcinod (0, 10, 21, and 41 mg/kg, orally administered once daily for 42 weeks) significantly increased average body weight (+7.3%) compared to the solvent control group and improved skeletal and cardiac disease phenotypes in DMD mice [3]. |
| Synonyms | Nitronaproxen, Naproxen-N-butyl nitrate, HCT-3012, HCT3012, AZD3582, AZD 3582 |
| Molecular Weight | 347.36 |
| Formula | C18H21NO6 |
| Cas No. | 163133-43-5 |
| Relative Density. | 1.213 |
| Color | Yellow |
| Appearance | Oil |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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