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Naproxcinod
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Catalog No. T33595Cas No. 163133-43-5
Alias Nitronaproxen, Naproxen-N-butyl nitrate, HCT-3012, HCT3012, AZD3582, AZD 3582
Naproxcinod is a derivative of naproxen exhibiting analgesic and anti-inflammatory activity. As a cyclooxygenase (COX)-inhibitory nitric oxide donor (CINOD), it is indicated for osteoarthritis and inflammatory conditions.
Naproxcinod
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Purity: 99.85%
Catalog No. T33595Alias Nitronaproxen, Naproxen-N-butyl nitrate, HCT-3012, HCT3012, AZD3582, AZD 3582Cas No. 163133-43-5
Naproxcinod is a derivative of naproxen exhibiting analgesic and anti-inflammatory activity. As a cyclooxygenase (COX)-inhibitory nitric oxide donor (CINOD), it is indicated for osteoarthritis and inflammatory conditions.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $293 | - | In Stock | |
| 5 mg | $722 | - | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,520 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock | |
| 100 mg | $2,500 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.85%
Appearance:Oil
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Naproxcinod is a derivative of naproxen exhibiting analgesic and anti-inflammatory activity. As a cyclooxygenase (COX)-inhibitory nitric oxide donor (CINOD), it is indicated for osteoarthritis and inflammatory conditions. |
| In vitro | Naproxcinod (1-30 μM, 15 minutes) increased cGMP levels in a concentration-dependent manner, reaching up to 27 times the baseline level [1]. Naproxcinod (1-100 μM, 8 hours) enhanced HO-1 mRNA expression in endothelial cells in a concentration-dependent manner [2]. |
| In vivo | Naproxcinod (0, 10, 21, and 41 mg/kg, orally administered once daily for 42 weeks) significantly increased average body weight (+7.3%) compared to the solvent control group and improved skeletal and cardiac disease phenotypes in DMD mice [3]. |
| Synonyms | Nitronaproxen, Naproxen-N-butyl nitrate, HCT-3012, HCT3012, AZD3582, AZD 3582 |
| Molecular Weight | 347.36 |
| Formula | C18H21NO6 |
| Cas No. | 163133-43-5 |
| Smiles | [O-][N+](OCCCCOC([C@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C)=O)=O |
| Relative Density. | 1.213 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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