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Ciglitazone

Name: Ciglitazone
Brand: TargetMol
SKU: T19710
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T19710Cas No. 74772-77-3

Alias U-63287, U 63287, Ciglitazona, ADD-3878, ADD3878, ADD 3878

Ciglitazone (ADD 3878) is a potent and selective PPARγ agonist (EC50: 3 μM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation of th17 cells, decreases insulin levels, vascular endothelial growth factor production and blood pressure, and induces cell cycle arrest in gastric cancer cells. Selegiline induces apoptosis in opossum kidney epithelial cells and activates nuclear translocation of p38 MAPK and apoptosis-inducing factor (AIF). Ciglitazone exhibits hypoglycaemic activity in animal models of obesity and hyperglycaemia.

Ciglitazone

🥰Excellent

Purity: 99.59%

Catalog No. T19710Alias U-63287, U 63287, Ciglitazona, ADD-3878, ADD3878, ADD 3878Cas No. 74772-77-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$42	-	In Stock
5 mg	$91	In Stock	In Stock
10 mg	$132	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.59%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Ciglitazone (ADD 3878) is a potent and selective PPARγ agonist (EC50: 3 μM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation of th17 cells, decreases insulin levels, vascular endothelial growth factor production and blood pressure, and induces cell cycle arrest in gastric cancer cells. Selegiline induces apoptosis in opossum kidney epithelial cells and activates nuclear translocation of p38 MAPK and apoptosis-inducing factor (AIF). Ciglitazone exhibits hypoglycaemic activity in animal models of obesity and hyperglycaemia.
Targets&IC50	PPARγ:3 μM(EC50)
In vitro	Ciglitazone (0-20 μM ; 24 hours) ciglitazone causes the generation of ROS and an increase in intracellular Ca2+ and induces apoptosis through a PPAR-independent mechanism.[4]
In vivo	Ciglitazone (100 mg/kg/day ; 2 days ; C57BL/6J-ob/ob mice) elicits a drastic fall in blood glucose.[3] Ciglitazone (100 mg/kg/day ; 41-44 days ; ob/ob mice) degranulation of islet beta-cells and increased pancreatic insulin content are observed.[3]
Synonyms	U-63287, U 63287, Ciglitazona, ADD-3878, ADD3878, ADD 3878

Chemical Properties

Molecular Weight	333.45
Formula	C₁₈H₂₃NO₃S
Cas No.	74772-77-3
Smiles	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1
Relative Density.	1.189 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (269.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (9.9 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9990 mL	14.9948 mL	29.9895 mL	149.9475 mL
5 mM	0.5998 mL	2.9990 mL	5.9979 mL	29.9895 mL
10 mM	0.2999 mL	1.4995 mL	2.9990 mL	14.9948 mL
20 mM	0.1499 mL	0.7497 mL	1.4995 mL	7.4974 mL
50 mM	0.0600 mL	0.2999 mL	0.5998 mL	2.9990 mL
100 mM	0.0300 mL	0.1499 mL	0.2999 mL	1.4995 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc