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S 18986

🥰Excellent
Catalog No. T16816Cas No. 175340-20-2

S 18986 is a selective, orally active, brain-penetrant positive allosteric modulator of AMPA-type receptors that enhances cognition in rodents by inducing the release of noradrenaline and acetylcholine in the rat hippocampus, subsequently improving object-recognition memory.

S 18986

S 18986

🥰Excellent
Purity: 99.64%
Catalog No. T16816Cas No. 175340-20-2
S 18986 is a selective, orally active, brain-penetrant positive allosteric modulator of AMPA-type receptors that enhances cognition in rodents by inducing the release of noradrenaline and acetylcholine in the rat hippocampus, subsequently improving object-recognition memory.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$30In StockIn Stock
5 mg$58In StockIn Stock
10 mg$98In StockIn Stock
25 mgPreferentialIn StockIn Stock
50 mgPreferentialIn StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.64%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
S 18986 is a selective, orally active, brain-penetrant positive allosteric modulator of AMPA-type receptors that enhances cognition in rodents by inducing the release of noradrenaline and acetylcholine in the rat hippocampus, subsequently improving object-recognition memory.
In vivo
S 18986 displays antiamnesic properties in middle-aged rodents in spatial memory models. S 18986 is robust memory-enhancing effects in middle-aged animals compared with aged ones. S 18986 (5-50 mg/kg; i.p.) obviously enhances both the induction and the maintenance of 4 and 20 bursts tetanus-evoked potentiation [1].
Chemical Properties
Molecular Weight224.28
FormulaC10H12N2O2S
Cas No.175340-20-2
SmilesO=S1(=O)C=2C(N3[C@@](N1)(CCC3)[H])=CC=CC2
Relative Density.1.46 g/cm3 (Predicted)
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (267.52 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (11.15 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.4587 mL22.2936 mL44.5871 mL222.9356 mL
5 mM0.8917 mL4.4587 mL8.9174 mL44.5871 mL
10 mM0.4459 mL2.2294 mL4.4587 mL22.2936 mL
20 mM0.2229 mL1.1147 mL2.2294 mL11.1468 mL
50 mM0.0892 mL0.4459 mL0.8917 mL4.4587 mL
100 mM0.0446 mL0.2229 mL0.4459 mL2.2294 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

S-18986S18986S 18986AMPA
Related Tags: buy S 18986 | purchase S 18986 | S 18986 cost | order S 18986 | S 18986 chemical structure | S 18986 in vivo | S 18986 formula | S 18986 molecular weight
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