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TC13172

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Catalog No. T17010Cas No. 2093393-05-4
Alias TC 13172

TC13172 is a potent and covalent inhibitor that specifically targets the mixed lineage kinase domain-like protein (MLKL), exhibiting significant selectivity for MLKL over the closely related receptor-interacting serine/threonine kinase 1 (RIPK1) and RIPK3 at a concentration of 10 µM.TC13172 effectively inhibits necroptosis induced by the TSZ combination (TNF-α, a Smac mimetic, and Z-VAD-FMK) in HT-29 cells with a EC50 of 2 nM and, at 100 nM, blocks TSZ-induced oligomerization and plasma membrane translocation of MLKL.

TC13172

TC13172

😃Good
Catalog No. T17010Alias TC 13172Cas No. 2093393-05-4
TC13172 is a potent and covalent inhibitor that specifically targets the mixed lineage kinase domain-like protein (MLKL), exhibiting significant selectivity for MLKL over the closely related receptor-interacting serine/threonine kinase 1 (RIPK1) and RIPK3 at a concentration of 10 µM.TC13172 effectively inhibits necroptosis induced by the TSZ combination (TNF-α, a Smac mimetic, and Z-VAD-FMK) in HT-29 cells with a EC50 of 2 nM and, at 100 nM, blocks TSZ-induced oligomerization and plasma membrane translocation of MLKL.
Pack SizePriceAvailabilityQuantity
5 mg$3478-10 weeks
25 mg$9878-10 weeks
50 mg$1,3608-10 weeks
100 mg$2,1908-10 weeks
1 mL x 10 mM (in DMSO)$3468-10 weeks
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Product Introduction

Bioactivity
Description
TC13172 is a potent and covalent inhibitor that specifically targets the mixed lineage kinase domain-like protein (MLKL), exhibiting significant selectivity for MLKL over the closely related receptor-interacting serine/threonine kinase 1 (RIPK1) and RIPK3 at a concentration of 10 µM.TC13172 effectively inhibits necroptosis induced by the TSZ combination (TNF-α, a Smac mimetic, and Z-VAD-FMK) in HT-29 cells with a EC50 of 2 nM and, at 100 nM, blocks TSZ-induced oligomerization and plasma membrane translocation of MLKL.
Targets&IC50
HT-29 cells:2±0.6 nM (EC50)
In vitro
TC13172 has anti-necroptotic activity against HT-29 cell lines with an EC50 value of 2 nM. [1]
SynonymsTC 13172
Chemical Properties
Molecular Weight388.4
FormulaC17H16N4O5S
Cas No.2093393-05-4
SmilesO=C1C2=C(N=C(N2C)S(=O)(=O)C)N(C(=O)N1C)CC#CC=3C=CC=C(O)C3
Relative Density.1.45 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 20 mg/mL (51.49 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5747 mL12.8733 mL25.7467 mL128.7333 mL
5 mM0.5149 mL2.5747 mL5.1493 mL25.7467 mL
10 mM0.2575 mL1.2873 mL2.5747 mL12.8733 mL
20 mM0.1287 mL0.6437 mL1.2873 mL6.4367 mL
50 mM0.0515 mL0.2575 mL0.5149 mL2.5747 mL

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