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TC13172 is a potent and covalent inhibitor that specifically targets the mixed lineage kinase domain-like protein (MLKL), exhibiting significant selectivity for MLKL over the closely related receptor-interacting serine/threonine kinase 1 (RIPK1) and RIPK3 at a concentration of 10 µM.TC13172 effectively inhibits necroptosis induced by the TSZ combination (TNF-α, a Smac mimetic, and Z-VAD-FMK) in HT-29 cells with a EC50 of 2 nM and, at 100 nM, blocks TSZ-induced oligomerization and plasma membrane translocation of MLKL.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $347 | 8-10 weeks | |
25 mg | $987 | 8-10 weeks | |
50 mg | $1,360 | 8-10 weeks | |
100 mg | $2,190 | 8-10 weeks | |
1 mL x 10 mM (in DMSO) | $346 | 8-10 weeks |
Description | TC13172 is a potent and covalent inhibitor that specifically targets the mixed lineage kinase domain-like protein (MLKL), exhibiting significant selectivity for MLKL over the closely related receptor-interacting serine/threonine kinase 1 (RIPK1) and RIPK3 at a concentration of 10 µM.TC13172 effectively inhibits necroptosis induced by the TSZ combination (TNF-α, a Smac mimetic, and Z-VAD-FMK) in HT-29 cells with a EC50 of 2 nM and, at 100 nM, blocks TSZ-induced oligomerization and plasma membrane translocation of MLKL. |
Targets&IC50 | HT-29 cells:2±0.6 nM (EC50) |
In vitro | TC13172 has anti-necroptotic activity against HT-29 cell lines with an EC50 value of 2 nM. [1] |
Synonyms | TC 13172 |
Molecular Weight | 388.4 |
Formula | C17H16N4O5S |
Cas No. | 2093393-05-4 |
Smiles | O=C1C2=C(N=C(N2C)S(=O)(=O)C)N(C(=O)N1C)CC#CC=3C=CC=C(O)C3 |
Relative Density. | 1.45 g/cm3 (Predicted) |
Color | White |
Appearance | Solid |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 20 mg/mL (51.49 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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