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4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His), Biotinylated
(Synonyms: tumor necrosis factor receptor superfamily, member 9, ILA, CDw137, CD137, 4-1BB) Copy Product InfoSynonyms: tumor necrosis factor receptor superfamily, member 9, ILA, CDw137, CD137, 4-1BB
Catalog No. TMPY-05105 Copy Product Info
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.7 kDa and the accession number is Q07011.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $112 | 7-10 days | 7-10 days | |
| 10 µg | $183 | 7-10 days | 7-10 days | |
| 20 µg | $306 | 7-10 days | 7-10 days | |
| 50 µg | $492 | 7-10 days | 7-10 days | |
| 100 µg | $842 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Recombinant Human TNFSF9 / 4-1BBL / CD137L Protein (Fc Tag, ECD) at 2 μg/mL (100 μL/well) can bind Recombinant Human CD137 / 4-1BB / TNFRSF9 Protein (His Tag), Biotinylated , the EC50 is 50-180 ng/mL. |
| Description | 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.7 kDa and the accession number is Q07011. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | Q07011 |
| Construction | A DNA sequence encoding the TNFRSF9 (NP_001552.2) (Met1-Gln186) was expressed with a polyhistidine tag at the C-terminus. The purified protein was biotinylated in vitro. Predicted N terminal: Leu 24 |
| Protein Purity | > 95 % as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing Sterile PBS. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Synonyms | tumor necrosis factor receptor superfamily, member 9, ILA, CDw137, CD137, 4-1BB |
| Research Background | CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+and CD8+T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. Crosslinking of CD137 on activated T cells has shown promise in enhancing anti-tumor immune responses in murine models, and agonistic anti-CD137 antibodies are currently being tested in phase I clinical trials. Soluble forms of CD137 (sCD137) are generated by differential splicing. sCD137 can bind to CD137 ligand to antagonize the costimulatory activities of the membrane-bound CD137 and reduce T cell proliferation and IL-2 secretion.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| Molecular Weight | 18.7 kDa (predicted) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His), Biotinylated chemical structure | 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His), Biotinylated molecular weight
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