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TTA-A8

Name: TTA-A8
Brand: TargetMol
SKU: T71990
Price: 278 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T71990Cas No. 1146395-46-1

TTA-A8 is an antagonist of T-type calcium channel.

TTA-A8

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Purity: 99.22%

Catalog No. T71990Cas No. 1146395-46-1

TTA-A8 is an antagonist of T-type calcium channel.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$278	-	In Stock
5 mg	$679	-	In Stock
10 mg	$826	-	In Stock
25 mg	$1,100	-	In Stock
50 mg	$1,380	-	In Stock
100 mg	$1,750	-	In Stock
200 mg	$2,360	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.22%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

TTA-A8 AI Summary

TTA-A8 exhibits a range of bioactivities, including antagonist activity at T-type calcium channels with a Ki value of 5.5 nM and IC50 values at both depolarized and hyperpolarized states. It also shows moderate inhibition of sodium and L-type calcium channels. In vivo, the compound demonstrates anticonvulsant activity in rats, affects the sleep-wake cycle, and exhibits activity at PXR (pregnane X receptor). Its pharmacokinetic profile in various animal models includes systemic clearance, volume of distribution, bioavailability, plasma protein binding with a value of 83.04%, and half-life measurements..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

TTA-A8 is an antagonist of T-type calcium channel.

Chemical Properties

Molecular Weight	430.42
Formula	C₂₂H₂₁F₃N₄O₂
Cas No.	1146395-46-1
Smiles	C[C@@H](NC(=O)Cc1ccc(cc1)-c1nccnc1C)c1ccc(OCC(F)(F)F)cn1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (116.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3233 mL	11.6166 mL	23.2331 mL	116.1656 mL
5 mM	0.4647 mL	2.3233 mL	4.6466 mL	23.2331 mL
10 mM	0.2323 mL	1.1617 mL	2.3233 mL	11.6166 mL
20 mM	0.1162 mL	0.5808 mL	1.1617 mL	5.8083 mL
50 mM	0.0465 mL	0.2323 mL	0.4647 mL	2.3233 mL
100 mM	0.0232 mL	0.1162 mL	0.2323 mL	1.1617 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc