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IACS-8779
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Catalog No. T11595Cas No. 2243079-26-5
IACS-8779 is a potent STING agonist that efficiently stimulates interferon gene activity and exhibits strong systemic antitumor effects.
IACS-8779
Copy Product Info😃Good
Catalog No. T11595Cas No. 2243079-26-5
IACS-8779 is a potent STING agonist that efficiently stimulates interferon gene activity and exhibits strong systemic antitumor effects.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | Inquiry | 3-6 months | 3-6 months | |
| 50 mg | Inquiry | 3-6 months | 3-6 months | |
| 100 mg | Inquiry | 3-6 months | 3-6 months |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | IACS-8779 is a potent STING agonist that efficiently stimulates interferon gene activity and exhibits strong systemic antitumor effects. |
| In vivo | Mice bilaterally implanted with B16-Ova tumors received intra-tumoral injections of IACS-8779 (compound 1a) at a 10 μg dose solely on one flank at intervals of three days, specifically on days 6, 9, and 12 post-implantation. While IACS-8779 demonstrated comparable antitumor efficacy on the treated flank, it elicited superior tumor regression on the untreated, contralateral flank. This indicates a stronger systemic immune response by IACS-8779 than that achieved by benchmark analogs. Furthermore, treatment with IACS-8779 resulted in a higher rate of mice being cured of tumors on both flanks, surpassing the outcomes observed with benchmark treatments. |
| Molecular Weight | 689.55 |
| Formula | C21H25N9O10P2S2 |
| Cas No. | 2243079-26-5 |
| Smiles | OC1[C@@]2([C@@H](O[C@@]1(COP(=O)(S)O[C@@]3([C@@](COP(=O)(S)O2)(O[C@H]([C@@H]3O)N4C=5C(C=C4)=C(N)N=CN5)[H])[H])[H])N6C=7C(N=C6)=C(N)N=CN7)[H] |
| Relative Density. | 2.33 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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