(D)-PPA 1 TFA

Name: (D)-PPA 1 TFA
Brand: TargetMol
SKU: T78222
Rating: 4.5 (1 reviews)

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Catalog No. T78222

(D)-PPA 1 TFA, a hydrolysis-resistant D-peptide antagonist, is a potent PD-1/PD-L1 inhibitor with an affinity for PD-1 of 0.51 μM, demonstrating efficacy both in vitro and in vivo [1].

(D)-PPA 1 TFA

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Catalog No. T78222

(D)-PPA 1 TFA, a hydrolysis-resistant D-peptide antagonist, is a potent PD-1/PD-L1 inhibitor with an affinity for PD-1 of 0.51 μM, demonstrating efficacy both in vitro and in vivo [1].

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Product Introduction

Bioactivity

Description	(D)-PPA 1 TFA, a hydrolysis-resistant D-peptide antagonist, is a potent PD-1/PD-L1 inhibitor with an affinity for PD-1 of 0.51 μM, demonstrating efficacy both in vitro and in vivo [1].
In vitro	(D)-PPA 1 TFA at concentrations of (0.2 mg/mL, 1.0 mg/mL) inhibits the interaction between PD-1 and PD-L1 at 1.0 mg/mL [1]. (D)-PPA 1 (3.125-100 μM; 24 h, 48 h) does not directly kill tumor cells and has no effect on the growth of CT26 cells [1].
In vivo	(D)-PPA 1 TFA administered at a dose of 2 mg/kg through subcutaneous or intraperitoneal injection once daily for seven consecutive days inhibited the growth of CT26 tumors in mice [1]. Additionally, a single intravenous dose of 40 μg/mouse in 200 μL demonstrated the capability to target tumor tissue in CT26 tumor-bearing mice [1].

Chemical Properties

Molecular Weight	1669.67
Formula	C₇₂H₉₉F₃N₂₀O₂₃
Sequence	D-{Asn-Tyr-Ser-Lys-Pro-Thr-Asp-Arg-Gln-Tyr-His-Phe}
Sequence Short	D-{NYSKPTDRQYHF}

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc