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Anti-CXCR3 Polyclonal Antibody
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Catalog No. TMAB-00508
Alias Mig-R, MigR, IP10-R, GPR9, CMKAR3, CKR-L2, CD183, CD182
Anti-CXCR3 Polyclonal Antibody is a Rabbit antibody targeting CXCR3. Anti-CXCR3 Polyclonal Antibody can be used in WB.
Anti-CXCR3 Polyclonal Antibody
Anti-CXCR3 Polyclonal Antibody
😃Good
Catalog No. TMAB-00508Alias Mig-R, MigR, IP10-R, GPR9, CMKAR3, CKR-L2, CD183, CD182
Anti-CXCR3 Polyclonal Antibody is a Rabbit antibody targeting CXCR3. Anti-CXCR3 Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $222 | 7-10 days | |
| 100 μL | $372 | 7-10 days | |
| 200 μL | $527 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-CXCR3 Polyclonal Antibody is a Rabbit antibody targeting CXCR3. Anti-CXCR3 Polyclonal Antibody can be used in WB. |
| Synonyms | Mig-R, MigR, IP10-R, GPR9, CMKAR3, CKR-L2, CD183, CD182 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Dog,Pig,Cow,Rabbit,GuineaPig) |
| Verified Activity | Sample: Lane 1: Mouse Blood cell tissue lysates Lane 2: Rat Blood cell tissue lysates Primary: Anti-CXCR3 (TMAB-00508) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kDa Observed band size: 40 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]. |
| Immunogen | KLH conjugated synthetic peptide: human CXCR3 |
| Antigen Species | Human |
| Gene Name | CXCR3 |
| Gene ID | |
| Protein Name | C-X-C chemokine receptor type 3 |
| Uniprot ID | |
| Biology Area | Chemokines,Alpha Chemokine Rec. (CXCR),Calcium Signaling,GPCR |
| Function | Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3 mediates the activity of CXCL11. |
| Molecular Weight | Theoretical: 41 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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