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Anti-HER4/ERBB4 Antibody (8W756) is a Mouse antibody targeting HER4/ERBB4. Anti-HER4/ERBB4 Antibody (8W756) can be used in WB,IP,IF,IHC-P,FCM.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $296 | 7-10 days | |
100 μL | $428 | 7-10 days |
Description | Anti-HER4/ERBB4 Antibody (8W756) is a Mouse antibody targeting HER4/ERBB4. Anti-HER4/ERBB4 Antibody (8W756) can be used in WB,IP,IF,IHC-P,FCM. |
Reactivity | Human,Mouse,Rat |
Application | |
Recommended Dose | WB: 1:100-1000; IHC-P: 1:50-500; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate); FCM: 1 μg per 1 x 106 cells |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | Hybridoma Monoclonal Antibody |
Purification | ProA affinity purified |
Appearance | Liquid |
Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
Research Background | The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum. |
Conjucates | Unconjugated |
Immunogen | Amino acids 1280-1308 at C-terminus of ErbB-4 of human origin |
Antigen Species | human |
Uniprot ID |
Molecular Weight | Theoretical: 180 kDa. |
Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. |
Transport | Shipping with blue ice. |
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