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TOPBioactivityChemical infoStorage&SolubilityCalculator

Cyclotraxin B acetate(1203586-72-4 free base)

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Catalog No. TP2068L

Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.

Cyclotraxin B acetate(1203586-72-4 free base)
Other Forms of Cyclotraxin B acetate(1203586-72-4 free base):

Cyclotraxin B acetate(1203586-72-4 free base)

🥰Excellent
Purity: 99.42%
Catalog No. TP2068L
Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$173In StockIn Stock
5 mg$392In StockIn Stock
10 mg$589In StockIn Stock
25 mg$943In StockIn Stock
50 mg$1,280In StockIn Stock
100 mg$1,720In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.42%
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COA LCMS

Product Introduction

Bioactivity
Description
Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.
Targets&IC50
TrkB:0.30 nM
Chemical Properties
Molecular Weight1260.42
FormulaC50H77N13O19S3
SmilesC[C@@H](O)[C@H]1C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(NCC(N[C@H](C(O)=O)CSSC[C@H](N)C(N[C@@H](CC(N)=O)C(N2CCC[C@H]2C(N[C@@H](CCSC)C(NCC(N[C@@H](CC3=CC=C(O)C=C3)C(N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(C)O
Relative Density.no data available
SequenceH-Cys(1)-Asn-Pro-Met-Gly-Tyr-Thr-Lys-Glu-Gly-Cys(1)-OH
Sequence ShortCNPMGYTKEGC
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mM, Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.7934 mL3.9669 mL7.9339 mL39.6693 mL
5 mM0.1587 mL0.7934 mL1.5868 mL7.9339 mL
10 mM0.0793 mL0.3967 mL0.7934 mL3.9669 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

TrkreceptorTrkBTrk receptorCyclotraxin B acetate(1203586-72-4 free base)Cyclotraxin B acetate(1203586724 free base)Cyclotraxin B acetate(1203586 72 4 free base)
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