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FX-11

Name: FX-11
Brand: TargetMol
SKU: T15362
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15362Cas No. 213971-34-7

Alias LDHA Inhibitor FX11

FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death. FX-11 appeared antitumor activity during xenotransplantation of lymphoma and pancreatic cancer.

FX-11

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Purity: 98.95%

Catalog No. T15362Alias LDHA Inhibitor FX11Cas No. 213971-34-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$142	In Stock	In Stock
25 mg	$236	In Stock	In Stock
50 mg	$348	-	In Stock
100 mg	$520	-	In Stock
1 mL x 10 mM (in DMSO)	$107	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.95%

Appearance:Solid

Color:Yellow to Brown

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death. FX-11 appeared antitumor activity during xenotransplantation of lymphoma and pancreatic cancer.
Targets&IC50	LDHA (HeLa cells):23.3 μM, DU-145 cells:32 ± 1.1 μM, LDHA:8 μM (Ki), PC3 cells:27 ± 1.1 μM
In vitro	FX-11 (9 μM, 24-48 h) induces activation of AMP kinase and phosphorylation of acetyl-CoA carboxylase, its substrate. FX-11 disrupts glycolysis and modifies cellular energy metabolism in P493 cells. [1] FX-11 (0-100 µM, 72 h) impedes cell proliferation in BxPc-3 and MIA PaCa-2 cells. [2]
In vivo	FX-11 (42 µg/mouse; IP, administered daily for 10-14 days) suppresses P493 tumor growth.[1] FX-11 (0-2 mg/kg, IP, daily, for 3 weeks) notably retards tumor growth.[2]
Synonyms	LDHA Inhibitor FX11

Chemical Properties

Molecular Weight	350.41
Formula	C₂₂H₂₂O₄
Cas No.	213971-34-7
Smiles	CCCc1c(O)c(O)c(C(O)=O)c2cc(Cc3ccccc3)c(C)cc12
Relative Density.	1.260 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 260 mg/mL (741.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (14.27 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8538 mL	14.2690 mL	28.5380 mL	142.6900 mL
5 mM	0.5708 mL	2.8538 mL	5.7076 mL	28.5380 mL
10 mM	0.2854 mL	1.4269 mL	2.8538 mL	14.2690 mL
20 mM	0.1427 mL	0.7134 mL	1.4269 mL	7.1345 mL
50 mM	0.0571 mL	0.2854 mL	0.5708 mL	2.8538 mL
100 mM	0.0285 mL	0.1427 mL	0.2854 mL	1.4269 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc