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(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin

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Catalog No. TP2136Cas No. 73168-24-8
Alias [d(CH2)51,Tyr(Me)2]-AVP

Selective vasopressin V1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC50 values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and induces anxiolytic-like effects in the dorsal, but not ventral, hippocampus in vivo.

(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin

(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin

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Catalog No. TP2136Alias [d(CH2)51,Tyr(Me)2]-AVPCas No. 73168-24-8
Selective vasopressin V1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC50 values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and induces anxiolytic-like effects in the dorsal, but not ventral, hippocampus in vivo.
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1 mg$66335 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Selective vasopressin V1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC50 values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and induces anxiolytic-like effects in the dorsal, but not ventral, hippocampus in vivo.
Synonyms[d(CH2)51,Tyr(Me)2]-AVP
Chemical Properties
Molecular Weight1151.38
FormulaC52H74N14O12S2
Cas No.73168-24-8
SmilesO=C1CC2(SSC[C@@H](C(=O)N3[C@H](C(N[C@H](C(NCC(N)=O)=O)CCCNC(=N)N)=O)CCC3)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC5=CC=C(OC)C=C5)N1)CCCCC2
Relative Density.1.50 g/cm3 (Predicted)
Sequence{Pmp}-{Tyr(Me)}-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bond: Pmp1-Cys6) (Pmp=β-Mercapto-β,β-cyclopentamethylene-propionic acid)
Sequence Short{Pmp}-{Tyr(Me)}-FQNCPRG (Disulfide bond: Pmp1-Cys6) (Pmp=β-Mercapto-β,β-cyclopentamethylene-propionic acid)
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 2 mg/mL (1.74 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM0.8685 mL4.3426 mL8.6852 mL43.4261 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

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