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SAFit1

Name: SAFit1
Brand: TargetMol
SKU: T16835
Rating: 4.5 (1 reviews)

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Catalog No. T16835Cas No. 1643125-32-9

Alias SAFit 1

SAFit1 is a highly potent and selective inhibitor of FK506 binding protein 51 (FKBP51) with a Ki value of 4 ± 0.3 nM, extensively applied in stress biology, neuropsychiatric disorder research, and metabolic disease studies to dissect FKBP51-specific signaling pathways and evaluate its role as a therapeutic target distinct from closely related FKBP family members.

SAFit1

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Catalog No. T16835Alias SAFit 1Cas No. 1643125-32-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$74	8-10 weeks	8-10 weeks
5 mg	$179	8-10 weeks	8-10 weeks
10 mg	$313	8-10 weeks	8-10 weeks
25 mg	$662	8-10 weeks	8-10 weeks
50 mg	$1,090	8-10 weeks	8-10 weeks
100 mg	$1,880	8-10 weeks	8-10 weeks
1 mL x 10 mM (in DMSO)	$298	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	SAFit1 is a highly potent and selective inhibitor of FK506 binding protein 51 (FKBP51) with a Ki value of 4 ± 0.3 nM, extensively applied in stress biology, neuropsychiatric disorder research, and metabolic disease studies to dissect FKBP51-specific signaling pathways and evaluate its role as a therapeutic target distinct from closely related FKBP family members.
Targets&IC50	FKBP52:>50000 nM (KI), FKBP51:4±0.3 nM(ki)
In vitro	In neurodevelopmental assays involving N2a, SH-SY5Y neuroblastoma cell lines, and primary hippocampal neurons, SAFit1 acted as a selective FKBP51 inhibitor. It stimulated neurite outgrowth and promoted neuronal differentiation and extension over a concentration range of 1 to 1000 nM [1].
Synonyms	SAFit 1

Chemical Properties

Molecular Weight	747.87
Formula	C₄₂H₅₃NO₁₁
Cas No.	1643125-32-9
Smiles	[C@@H](C(=O)N1[C@H](C(O[C@H](CCC2=CC(OC)=C(OC)C=C2)C3=CC(OCC(O)=O)=CC=C3)=O)CCCC1)(C4=CC(OC)=C(OC)C(OC)=C4)C5CCCCC5
Relative Density.	1.211 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (106.97 mM), Sonication is recommended.

MEthanol: 125 mg/mL (167.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (4.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/MEthanol

	1mg	5mg	10mg	50mg
1 mM	1.3371 mL	6.6857 mL	13.3713 mL	66.8565 mL
5 mM	0.2674 mL	1.3371 mL	2.6743 mL	13.3713 mL
10 mM	0.1337 mL	0.6686 mL	1.3371 mL	6.6857 mL
20 mM	0.0669 mL	0.3343 mL	0.6686 mL	3.3428 mL
50 mM	0.0267 mL	0.1337 mL	0.2674 mL	1.3371 mL
100 mM	0.0134 mL	0.0669 mL	0.1337 mL	0.6686 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc