Shopping Cart

Remove All
Your shopping cart is currently empty

LIN28 inhibitor LI71

Name: LIN28 inhibitor LI71
Brand: TargetMol
SKU: T11850
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11850Cas No. 1357248-83-9

LIN28 inhibitor LI71 is a potent and cell-permeable compound that effectively abolishes LIN28-mediated oligouridylation, with an IC50 of 7 µM (micromolar).

LIN28 inhibitor LI71

🥰Excellent

Purity: 95.88%

Catalog No. T11850Cas No. 1357248-83-9

LIN28 inhibitor LI71 is a potent and cell-permeable compound that effectively abolishes LIN28-mediated oligouridylation, with an IC50 of 7 µM (micromolar).

Pack Size	Price	Availability
1 mg	$139	In Stock
5 mg	$347	In Stock
10 mg	$519	In Stock
25 mg	$865	In Stock
50 mg	$1,180	In Stock
100 mg	$1,620	In Stock
1 mL x 10 mM (in DMSO)	$379	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:95.88%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	LIN28 inhibitor LI71 is a potent and cell-permeable compound that effectively abolishes LIN28-mediated oligouridylation, with an IC50 of 7 µM (micromolar).
Targets&IC50	LIN28:7 uM (IC50)
In vitro	LIN28 inhibitor LI71 directly binds the cold shock domain (CSD) to suppress LIN28's activity against let-7 in leukemia cells and embryonic stem cells.

Chemical Properties

Molecular Weight	335.4
Formula	C₂₁H₂₁NO₃
Cas No.	1357248-83-9
Smiles	[H][C@]12CC=C[C@@]1([H])c1cccc(OCC)c1N[C@H]2c1ccc(cc1)C(O)=O
Relative Density.	no data available
Color	Purple
Appearance	Liquid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (81.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9815 mL	14.9076 mL	29.8151 mL	149.0757 mL
5 mM	0.5963 mL	2.9815 mL	5.9630 mL	29.8151 mL
10 mM	0.2982 mL	1.4908 mL	2.9815 mL	14.9076 mL
20 mM	0.1491 mL	0.7454 mL	1.4908 mL	7.4538 mL
50 mM	0.0596 mL	0.2982 mL	0.5963 mL	2.9815 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc