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NIBR-17

Name: NIBR-17
Brand: TargetMol
SKU: T22377
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22377Cas No. 944396-88-7

NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.

NIBR-17

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Purity: 97.79%

Catalog No. T22377Cas No. 944396-88-7

NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	In Stock	In Stock
5 mg	$141	In Stock	In Stock
10 mg	$209	In Stock	In Stock
25 mg	$336	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$166	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.79%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

NIBR-17 AI Summary

NIBR-17 exhibits potent inhibitory activity against PI3K isoforms (PI3Kalpha, PI3Kbeta, PI3Kgamma, and PI3Kdelta) with IC50 values ranging from 9.0 to 92.0 nM. It also shows antiproliferative activity against human A2780 cells with an EC50 of 730.0 nM and inhibits mTOR with an IC50 of 4000.0 nM. In xenografted nu/nu mice, NIBR-17 demonstrates significant antitumor activity by inhibiting Akt phosphorylation and reducing tumor growth at specific dosage levels. Additionally, it has favorable pharmacokinetic properties, including high oral bioavailability, moderate clearance, and a steady-state volume of distribution..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.
Targets&IC50	PI3Kγ:9 nM, PI3Kα:1 nM, PI3Kβ:9.2 nM

Chemical Properties

Molecular Weight	380.4
Formula	C₁₈H₂₀N₈O₂
Cas No.	944396-88-7
Smiles	COc1ccc(Nc2cc(nc(n2)N2CCOCC2)-c2cnc(N)nc2)cn1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (144.58 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6288 mL	13.1441 mL	26.2881 mL	131.4406 mL
5 mM	0.5258 mL	2.6288 mL	5.2576 mL	26.2881 mL
10 mM	0.2629 mL	1.3144 mL	2.6288 mL	13.1441 mL
20 mM	0.1314 mL	0.6572 mL	1.3144 mL	6.5720 mL
50 mM	0.0526 mL	0.2629 mL	0.5258 mL	2.6288 mL
100 mM	0.0263 mL	0.1314 mL	0.2629 mL	1.3144 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc