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TAT (48-57) (Synonyms: TAT 48-57)

Name: TAT (48-57)
Brand: TargetMol
SKU: TP1744
Price: 63 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. TP1744 Copy Product Info

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TAT (48-57) is a classical arginine-rich cell-penetrating peptide (CPP) derived from the HIV-1 TAT protein sequence. It possesses potent receptor-independent membrane permeability, efficiently mediating the cytoplasmic delivery of various macromolecular payloads like proteins and nanodrugs.

TAT (48-57)

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Catalog No. TP1744

Synonyms TAT 48-57

Cas No. 253141-50-3

Pack Size	Price	USA Stock	Global Stock
1 mg	$63	-	In Stock
5 mg	$148	7-10 days	7-10 days
10 mg	$229	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	TAT (48-57) is a classical arginine-rich cell-penetrating peptide (CPP) derived from the HIV-1 TAT protein sequence. It possesses potent receptor-independent membrane permeability, efficiently mediating the cytoplasmic delivery of various macromolecular payloads like proteins and nanodrugs.
In vitro	TAT (48-57) is a cell-permeable peptide with high translocation efficiency and low cytotoxicity, serving as a carrier for macromolecules[1].
Synonyms	TAT 48-57

Chemical Properties

Molecular Weight	1396.65
Formula	C₅₅H₁₀₉N₃₁O₁₂
Cas No.	253141-50-3
Smiles	[C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)NC(CN)=O)=O)CCCCN)=O)CCCCN)=O)CCCNC(=N)N)=O)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCNC(=N)N
Relative Density.	1.55 g/cm3 (Predicted)
Sequence	Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg
Sequence Short	GRKKRRQRRR

Storage & Solubility Information

Storage

Keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (28.64 mM), Sonication is recommmended.

H2O: Soluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.7160 mL	3.5800 mL	7.1600 mL	35.7999 mL
5 mM	0.1432 mL	0.7160 mL	1.4320 mL	7.1600 mL
10 mM	0.0716 mL	0.3580 mL	0.7160 mL	3.5800 mL
20 mM	0.0358 mL	0.1790 mL	0.3580 mL	1.7900 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc