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Lupeol
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Catalog No. T2895Cas No. 545-47-1
Alias Monogynol B, Farganasterol, Fagarasterol, Clerodol, (3β,13ξ)-Lup-20(29)-en-3-ol
Lupeol (Monogynol B) is a novel androgen receptor inhibitor with anti-inflammatory and antioxidant activity.
Lupeol
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Purity: 99.96%
Catalog No. T2895Alias Monogynol B, Farganasterol, Fagarasterol, Clerodol, (3β,13ξ)-Lup-20(29)-en-3-olCas No. 545-47-1
Lupeol (Monogynol B) is a novel androgen receptor inhibitor with anti-inflammatory and antioxidant activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $30 | In Stock | In Stock | |
| 10 mg | $47 | In Stock | In Stock | |
| 25 mg | $67 | In Stock | In Stock | |
| 50 mg | $108 | In Stock | In Stock | |
| 100 mg | $177 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.96%
Color:White
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Product Introduction
Lupeol AI Summary
Lupeol exhibits a broad range of bioactivities, including cytotoxic, antitrypanosomal, antimalarial, antimicrobial, antifungal, antitubercular, antineuroinflammatory, and renoprotective effects. It shows cytotoxicity against multiple human cancer cell lines, such as MEL-2, KB, A2780, HepG2, Hep3B, Ca9-22, HeLa, and MDA-MB-231, with varying IC50 and ED50 values indicating potent to moderate cytotoxic effects. Additionally, it demonstrates antitrypanosomal activity against Trypanosoma brucei brucei, with high selectivity over mammalian cells, and antimalarial activity against Plasmodium falciparum, including chloroquine-sensitive and resistant strains.
The compound inhibits human topoisomerase 2alpha, farnesyltransferase, human liver microsomal enzymes CES2A1 and CES1A1, protein tyrosine phosphatase 1B, and reduces cell proliferation inhibition in multiple tested cell lines. It also shows significant antioxidant, hepatoprotective, antiinflammatory, and antidyslipidemic properties in various assays and animal models. Its renoprotective effects are noted by increased renal alkaline phosphatase and decreased lipid peroxidation in the kidney. Lupeol further exhibits antiviral activity against HIV1 and DENV2, and antifertility activity in rats.
While it shows weak or no inhibition against certain human cells and enzymes like human DNA topoisomerase 2 and Phytophthora cactorum, its diverse bioactivity profile suggests potential therapeutic applications across a wide spectrum of diseases and biological processes..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Lupeol (Monogynol B) is a novel androgen receptor inhibitor with anti-inflammatory and antioxidant activity. |
| Synonyms | Monogynol B, Farganasterol, Fagarasterol, Clerodol, (3β,13ξ)-Lup-20(29)-en-3-ol |
| Molecular Weight | 426.72 |
| Formula | C30H50O |
| Cas No. | 545-47-1 |
| Smiles | [H][C@]12[C@@H](CC[C@]1(C)CC[C@]1(C)[C@]2([H])CC[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])CC[C@@]12C)C(C)=C |
| Relative Density. | 0.977 g/cm3 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 1 mg/mL (2.34 mM), Sonication is recommended.  Ethanol: 10 mg/mL (23.43 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% EtOH+90% Corn Oil: 1 mg/mL (2.34 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O/Ethanol
Ethanol
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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