CD16 Protein, Cynomolgus, Recombinant (His)

Name: CD16 Protein, Cynomolgus, Recombinant (His)
Brand: TargetMol
SKU: TMPK-01115
Rating: 4.5 (1 reviews)

(Synonyms: IMD20, IgG Fc receptor III, IGFR3, Fc-γ RIII, FCRIIIA, FcRIII, FCR-10, FcgRIII, FCGR3, Fc-gamma RIII, FCG3, Fc γ RIIB, CD16A, CD16) Copy Product Info

Synonyms: IMD20, IgG Fc receptor III, IGFR3, Fc-γ RIII, FCRIIIA, FcRIII, FCR-10, FcgRIII, FCGR3, Fc-gamma RIII, FCG3, Fc γ RIIB, CD16A, CD16

Catalog No. TMPK-01115 Copy Product Info

Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for human Fc gamma RI, Fc gamma RIIA, Fc gamma RIIB, Fc gamma RIIIA, and FcRn receptors has been determined.A common set of IgG1 residues is involved in binding to all Fc gamma R; Fc gamma RII and Fc gamma RIII also utilize residues outside this common set.

CD16 Protein, Cynomolgus, Recombinant (His)

Pack Size	Price	USA Stock	Global Stock
5 µg	$46	7-10 days	7-10 days
10 µg	$72	7-10 days	7-10 days
20 µg	$115	7-10 days	7-10 days
50 µg	$222	7-10 days	7-10 days
100 µg	$371	7-10 days	7-10 days
200 µg	$673	7-10 days	7-10 days
500 µg	$1,490	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Rituximab captured on CM5 Chip via Protein A can bind Cynomolgus Fc gamma RIII, His Tag with an affinity constant of 0.251 μM as determined in SPR assay.
Description	Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for human Fc gamma RI, Fc gamma RIIA, Fc gamma RIIB, Fc gamma RIIIA, and FcRn receptors has been determined.A common set of IgG1 residues is involved in binding to all Fc gamma R; Fc gamma RII and Fc gamma RIII also utilize residues outside this common set.
Species	Cynomolgus
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q8SPW2-1
Construction	Gly17-Gln208
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	IMD20, IgG Fc receptor III, IGFR3, Fc-γ RIII, FCRIIIA, FcRIII, FCR-10, FcgRIII, FCGR3, Fc-gamma RIII, FCG3, Fc γ RIIB, CD16A, CD16
Research Background	Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for human Fc gamma RI, Fc gamma RIIA, Fc gamma RIIB, Fc gamma RIIIA, and FcRn receptors has been determined.A common set of IgG1 residues is involved in binding to all Fc gamma R; Fc gamma RII and Fc gamma RIII also utilize residues outside this common set.

Chemical Properties

Molecular Weight

23.1 kDa (predicted). Due to glycosylation, the protein migrates to 45-55 kDa based on Tris-Bis PAGE result.

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.