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RMC-0331

Name: RMC-0331
Brand: TargetMol
SKU: T38170
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38170Cas No. 2488788-52-7

Alias RM-023

RMC-0331 (RM-023) is an orally available and potent SOS1 inhibitor with potential anticancer activity, blocking RAS activation by disrupting RAS-SOS1 interactions.

RMC-0331

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Purity: 97.84%

Catalog No. T38170Alias RM-023Cas No. 2488788-52-7

RMC-0331 (RM-023) is an orally available and potent SOS1 inhibitor with potential anticancer activity, blocking RAS activation by disrupting RAS-SOS1 interactions.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$89	In Stock	In Stock
5 mg	$223	In Stock	In Stock
10 mg	$398	In Stock	In Stock
25 mg	$822	In Stock	In Stock
50 mg	$1,270	In Stock	In Stock
100 mg	$1,890	-	In Stock
200 mg	$2,550	-	In Stock
1 mL x 10 mM (in DMSO)	$238	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.84%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	RMC-0331 (RM-023) is an orally available and potent SOS1 inhibitor with potential anticancer activity, blocking RAS activation by disrupting RAS-SOS1 interactions.
Targets&IC50	GDP/GTP:71 nM
In vitro	The IC50 of RMC-0331 is 71 nM, as determined by in vitro GDP/GTP exchange rate measurements[1].
In vivo	In the SHP2 mutation model, RMC-0331 exhibits single-agent anti-tumor activity when administered orally at doses ranging from 100 to 250 mg/kg once daily in immunocompetent mice[1].
Synonyms	RM-023

Chemical Properties

Molecular Weight	499.91
Formula	C₂₂H₂₅ClF₃N₅O₃
Cas No.	2488788-52-7
Smiles	COC1(CCOCC1)C(=O)N1Cc2nc(Cl)nc(N[C@H](C)c3cc(N)cc(c3)C(F)(F)F)c2C1
Relative Density.	1.44 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (200.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0004 mL	10.0018 mL	20.0036 mL	100.0180 mL
5 mM	0.4001 mL	2.0004 mL	4.0007 mL	20.0036 mL
10 mM	0.2000 mL	1.0002 mL	2.0004 mL	10.0018 mL
20 mM	0.1000 mL	0.5001 mL	1.0002 mL	5.0009 mL
50 mM	0.0400 mL	0.2000 mL	0.4001 mL	2.0004 mL
100 mM	0.0200 mL	0.1000 mL	0.2000 mL	1.0002 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc