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RMC-0331

Name: RMC-0331
Brand: TargetMol
SKU: T38170
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38170Cas No. 2488788-52-7

Alias RM-023

RMC-0331 (RM-023) is an orally available and potent SOS1 inhibitor with potential anticancer activity, blocking RAS activation by disrupting RAS-SOS1 interactions.

RMC-0331

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Purity: 97.84%

Catalog No. T38170Alias RM-023Cas No. 2488788-52-7

RMC-0331 (RM-023) is an orally available and potent SOS1 inhibitor with potential anticancer activity, blocking RAS activation by disrupting RAS-SOS1 interactions.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$89	In Stock	In Stock
5 mg	$223	In Stock	In Stock
10 mg	$398	In Stock	In Stock
25 mg	$822	In Stock	In Stock
50 mg	$1,270	In Stock	In Stock
100 mg	$1,890	-	In Stock
200 mg	$2,550	-	In Stock
1 mL x 10 mM (in DMSO)	$238	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.84%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	RMC-0331 (RM-023) is an orally available and potent SOS1 inhibitor with potential anticancer activity, blocking RAS activation by disrupting RAS-SOS1 interactions.
Targets&IC50	GDP/GTP:71 nM
In vitro	The IC50 of RMC-0331 is 71 nM, as determined by in vitro GDP/GTP exchange rate measurements[1].
In vivo	In the SHP2 mutation model, RMC-0331 exhibits single-agent anti-tumor activity when administered orally at doses ranging from 100 to 250 mg/kg once daily in immunocompetent mice[1].
Synonyms	RM-023

Chemical Properties

Molecular Weight	499.91
Formula	C₂₂H₂₅ClF₃N₅O₃
Cas No.	2488788-52-7
Smiles	COC1(CCOCC1)C(=O)N1Cc2nc(Cl)nc(N[C@H](C)c3cc(N)cc(c3)C(F)(F)F)c2C1
Relative Density.	1.44 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (200.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0004 mL	10.0018 mL	20.0036 mL	100.0180 mL
5 mM	0.4001 mL	2.0004 mL	4.0007 mL	20.0036 mL
10 mM	0.2000 mL	1.0002 mL	2.0004 mL	10.0018 mL
20 mM	0.1000 mL	0.5001 mL	1.0002 mL	5.0009 mL
50 mM	0.0400 mL	0.2000 mL	0.4001 mL	2.0004 mL
100 mM	0.0200 mL	0.1000 mL	0.2000 mL	1.0002 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc