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RMC-0331

Catalog No. T38170 CAS 2488788-52-7

Synonyms: RM-023

RMC-0331 (RM-023) is an orally available and potent SOS1 inhibitor.RMC-0331 has potential anticancer activity, blocking RAS activation by disrupting RAS-SOS1 interactions.

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RMC-0331, CAS 2488788-52-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 372.00
10 mg	In stock	$ 663.00
25 mg	In stock	$ 1,370.00
50 mg	In stock	$ 2,120.00
100 mg	In stock	$ 3,160.00
1 mL * 10 mM (in DMSO)	In stock	$ 397.00

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Purity: 99.81%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	RMC-0331 (RM-023) is an orally available and potent SOS1 inhibitor.RMC-0331 has potential anticancer activity, blocking RAS activation by disrupting RAS-SOS1 interactions.
Targets&IC50	GDP/GTP:71 nM
In vitro	The IC50 of RMC-0331 is 71 nM, as determined by in vitro GDP/GTP exchange rate measurements[1].
In vivo	In the SHP2 mutation model, RMC-0331 exhibits single-agent anti-tumor activity when administered orally at doses ranging from 100 to 250 mg/kg once daily in immunocompetent mice[1].

Synonyms	RM-023
Molecular Weight	499.91
Formula	C22H25ClF3N5O3
CAS No.	2488788-52-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (200.04 mM), Sonication is recommended.

References and Literature

1. Buckl A,et al. Discovery of a potent, selective, and orally bioavailable SOS1 inhibitor, RMC-023, an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction[J]. Cancer Research, 2021, 81(13_Supplement): 1273-1273.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Immunology/Inflammation Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RMC-0331 2488788-52-7 MAPK Raf RMC 0331 RMC0331 RM-023 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.