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Luxdegalutamide

Name: Luxdegalutamide
Brand: TargetMol
SKU: T75129
Price: 318 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T75129Cas No. 2750830-09-0

Alias ARV-766

Luxdegalutamide (ARV-766) is a novel, potent, and orally bioavailable proteolytic targeting chimera (PROTAC) protein degrader that degrades not only wild-type AR but also clinically relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations.

Luxdegalutamide

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Purity: 99.95%

Catalog No. T75129Alias ARV-766Cas No. 2750830-09-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$318	In Stock	In Stock
5 mg	$768	In Stock	In Stock
10 mg	$1,180	In Stock	In Stock
25 mg	$1,780	In Stock	In Stock
50 mg	$2,320	In Stock	In Stock
100 mg	$2,970	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.95%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Luxdegalutamide (ARV-766) is a novel, potent, and orally bioavailable proteolytic targeting chimera (PROTAC) protein degrader that degrades not only wild-type AR but also clinically relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations.
Targets&IC50	P-gp:0.23 μM (vesicle assay), BCRP:1.55 μM (monolayer assay), P-gp:> 5 μM (monolayer assay), BCRP:0.21 μM (vesicle assay)
In vivo	Luxdegalutamide (ARV-766) significantly and dose-dependently inhibits tumor growth in mouse LNCaP and VCaP xenograft models.[2]
Synonyms	ARV-766

Chemical Properties

Molecular Weight	807.95
Formula	C₄₅H₅₄FN₇O₆
Cas No.	2750830-09-0
Smiles	O([C@H]1C(C)(C)[C@H](NC(=O)C2=CC=C(C=C2)N3CCC(CN4CCN(CC4)C5=CC(F)=C(C(N[C@@H]6C(=O)NC(=O)CC6)=O)C=C5)CC3)C1(C)C)C7=CC(OC)=C(C#N)C=C7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (309.43 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2377 mL	6.1885 mL	12.3770 mL	61.8850 mL
5 mM	0.2475 mL	1.2377 mL	2.4754 mL	12.3770 mL
10 mM	0.1238 mL	0.6189 mL	1.2377 mL	6.1885 mL
20 mM	0.0619 mL	0.3094 mL	0.6189 mL	3.0943 mL
50 mM	0.0248 mL	0.1238 mL	0.2475 mL	1.2377 mL
100 mM	0.0124 mL	0.0619 mL	0.1238 mL	0.6189 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc