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Luxdegalutamide

Name: Luxdegalutamide
Brand: TargetMol
SKU: T75129
Price: 318 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T75129Cas No. 2750830-09-0

Alias ARV-766

Luxdegalutamide (ARV-766) is a novel, potent, and orally bioavailable proteolytic targeting chimera (PROTAC) protein degrader that degrades not only wild-type AR but also clinically relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations.

Luxdegalutamide

🥰Excellent

Purity: 99.95%

Catalog No. T75129Alias ARV-766Cas No. 2750830-09-0

Pack Size	Price	Availability
1 mg	$318	In Stock
5 mg	$768	In Stock
10 mg	$1,180	In Stock
25 mg	$1,780	In Stock
50 mg	$2,320	In Stock
100 mg	$2,970	In Stock

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Purity:99.95%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Luxdegalutamide (ARV-766) is a novel, potent, and orally bioavailable proteolytic targeting chimera (PROTAC) protein degrader that degrades not only wild-type AR but also clinically relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations.
Targets&IC50	P-gp:> 5 μM (monolayer assay), BCRP:0.21 μM (vesicle assay), P-gp:0.23 μM (vesicle assay), BCRP:1.55 μM (monolayer assay)
In vivo	Luxdegalutamide (ARV-766) significantly and dose-dependently inhibits tumor growth in mouse LNCaP and VCaP xenograft models.[2]
Synonyms	ARV-766

Chemical Properties

Molecular Weight	807.95
Formula	C₄₅H₅₄FN₇O₆
Cas No.	2750830-09-0
Smiles	O([C@H]1C(C)(C)[C@H](NC(=O)C2=CC=C(C=C2)N3CCC(CN4CCN(CC4)C5=CC(F)=C(C(N[C@@H]6C(=O)NC(=O)CC6)=O)C=C5)CC3)C1(C)C)C7=CC(OC)=C(C#N)C=C7
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (309.43 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2377 mL	6.1885 mL	12.3770 mL	61.8850 mL
5 mM	0.2475 mL	1.2377 mL	2.4754 mL	12.3770 mL
10 mM	0.1238 mL	0.6189 mL	1.2377 mL	6.1885 mL
20 mM	0.0619 mL	0.3094 mL	0.6189 mL	3.0943 mL
50 mM	0.0248 mL	0.1238 mL	0.2475 mL	1.2377 mL
100 mM	0.0124 mL	0.0619 mL	0.1238 mL	0.6189 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc