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AChE-IN-94
Catalog No. T213263 Copy Product Info
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AChE-IN-94 is an orally active acetylcholinesterase (AChE) inhibitor capable of crossing the blood-brain barrier, demonstrating an IC50 of 0.40 μM and a Ki of 0.28 μM. It inhibits both spontaneous and AChE-mediated Aβ1-42 aggregation and alleviates cognitive/memory deficits in scopolamine-induced amnesia models. AChE-IN-94 is applicable in Alzheimer's disease (AD) research.
AChE-IN-94
Copy Product Info🥰Excellent
Catalog No. T213263
AChE-IN-94 is an orally active acetylcholinesterase (AChE) inhibitor capable of crossing the blood-brain barrier, demonstrating an IC50 of 0.40 μM and a Ki of 0.28 μM. It inhibits both spontaneous and AChE-mediated Aβ1-42 aggregation and alleviates cognitive/memory deficits in scopolamine-induced amnesia models. AChE-IN-94 is applicable in Alzheimer's disease (AD) research.
AChE-IN-94
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AChE-IN-94 is an orally active acetylcholinesterase (AChE) inhibitor capable of crossing the blood-brain barrier, demonstrating an IC50 of 0.40 μM and a Ki of 0.28 μM. It inhibits both spontaneous and AChE-mediated Aβ1-42 aggregation and alleviates cognitive/memory deficits in scopolamine-induced amnesia models. AChE-IN-94 is applicable in Alzheimer's disease (AD) research. |
| Targets&IC50 | AChE:0.4 μM |
| In vitro | AChE-IN-94 (Compound LB05) exhibits strong inhibitory activity against acetylcholinesterase (AChE), with an IC50 of 0.40 μM and an inhibition constant (Ki) of 0.28 μM. In concentrations ranging from 10-50 μM, AChE-IN-94 displaces propidium iodide (PI) from the peripheral anionic site (PAS) of AChE in a dose-dependent manner. Additionally, at concentrations of 5-20 μM over 48 hours, it inhibits Aβ 1-42 aggregation in a concentration-dependent manner. |
| In vivo | AChE-IN-94 (Compound LB05), administered at 5-20 mg/kg via oral gavage once daily for 7 consecutive days, has the potential to ameliorate scopolamine-induced cognitive deficits in male Wistar rats. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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