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Anticancer agent 43

Catalog No. T61046 CAS 2470015-35-9

Anticancer agent 43 is a potent anticancer agent that induces apoptosis through caspase 3, PARP1, and Bax protein-dependent pathways.Anticancer agent 43 induces DNA damage and can be used in the study of glioblastoma in rats.

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Anticancer agent 43, CAS 2470015-35-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 84.00
10 mg	In stock	$ 139.00
25 mg	In stock	$ 233.00
50 mg	In stock	$ 347.00
100 mg	In stock	$ 516.00
500 mg	In stock	$ 1,090.00

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Purity: 98.88%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

Anticancer agent 43 (compound 3a) exhibits selectivity towards human tumor cells, with an SI50 of 28.94[1]. In HepG2 cells treated with 45 µM for 24 hours, Anticancer agent 43 induces apoptosis through caspase 3, PARP1, and Bax-dependent pathways[1]. However, it has no effect on the transition of G1/S phases in HepG2 cells at the same concentration and time point[1]. Additionally, in various cell lines, including HCT116, MCF-7, HepG2, and Balb/c 3T3 cells, Anticancer agent 43 induces DNA damage at concentrations of 0.7, 45, and 55 µM, as evidenced by tail DNA and Olive Tail Moment (OTM) measurements[1].

Molecular Weight	336.36
Formula	C14H9FN2O3S2
CAS No.	2470015-35-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (297.30 mM), Sonication is recommended.

References and Literature

1. Kryshchyshyn-Dylevych A, et al. Synthesis of novel indole-thiazolidinone hybrid structures as promising scaffold with anticancer potential. Bioorg Med Chem. 2021; 50:116453.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Anticancer agent 43 2470015-35-9 Apoptosis inhibitor inhibit

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