Shopping Cart

Your shopping cart is currently empty

Pyrantel pamoate

Name: Pyrantel pamoate
Brand: TargetMol
SKU: T1259
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T1259Cas No. 22204-24-6

Alias Pyrantel embonate

Pyrantel pamoate (Pyrantel embonate) is a depolarizing neuromuscular blocking agent. This compound is commonly used as an anthelmintic to treat parasitic worm infections, effectively paralyzing nematodes by inhibiting their neuromuscular activity.

Pyrantel pamoate

Copy Product Info

😃Good

Purity: 99.71%

Catalog No. T1259Alias Pyrantel embonateCas No. 22204-24-6

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$34	In Stock	In Stock
500 mg	$60	In Stock	In Stock
1 g	$87	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.71%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Pyrantel pamoate AI Summary

Pyrantel pamoate demonstrates diverse bioactivities, functioning as both an inhibitor and an activator across various biological pathways and processes. It is a potent inhibitor of Human Galactosidase (GALK) and HSD17B4 with potencies of 42,128.5 nM and 31,622.8 nM, respectively. It inhibits Tau Fibril Formation with potencies of 15,848.9 nM and 14,125.4 nM via fluorescence polarization and Thioflavin T Binding, respectively. It shows inhibition of 15-hLO and 15-hLO-2 with potencies ranging from 25,059.4 nM to 31,622.8 nM, and inhibits Menin-MLL interaction in MLL-related leukemias at 14,125.4 nM. It is also an inhibitor of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia at 25,059.4 nM potency. Additionally, Pyrantel pamoate acts as an activator and substrate of Cytochrome P450 3A4 at 25,118.9 nM potency. It inhibits the vitamin D receptor (VDR), Polymerase Kappa, and USP1/UAF1, with respective potencies of 35,481.3 nM, 31,622.8 nM, and 50,118.7 nM. In terms of antiparasitic activity, Pyrantel pamoate acts effectively against Ancylostoma caninum isolates NT and PR, with an EC50 of 217,200.0 nM for isolate NT and 681,300.0 nM for isolate PR, and exhibits notable larval arrested morphology effects. Moreover, the compound inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells, with inhibition percentages of 31.41% and 34.84% at 10 µM concentration. It also displays antiviral activity against SARS-CoV-2 by inhibiting cytotoxicity in Caco-2 and VERO-6 cells, with an inhibition of -1.07% in Caco-2 cells and -0.17% in VERO-6 cells at 10 µM concentration. Furthermore, it inhibits SARS-CoV-2 3CL-Pro protease activity by 16.14% at 20 µM. Overall, Pyrantel pamoate shows potential as a multi-faceted therapeutic agent with activities spanning from enzyme inhibition and receptor modulation to antiparasitic and antiviral effects..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pyrantel pamoate (Pyrantel embonate) is a depolarizing neuromuscular blocking agent. This compound is commonly used as an anthelmintic to treat parasitic worm infections, effectively paralyzing nematodes by inhibiting their neuromuscular activity.
Synonyms	Pyrantel embonate

Chemical Properties

Molecular Weight	594.69
Formula	C₃₄H₃₀N₂O₆S
Cas No.	22204-24-6
Smiles	C1(=NCCCN1C)/C=C/c1cccs1.C(c1c(c(cc2c1cccc2)C(=O)O)O)c1c(c(cc2c1cccc2)C(=O)O)O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16.67 mg/mL (28.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.36 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6815 mL	8.4077 mL	16.8155 mL	84.0774 mL
5 mM	0.3363 mL	1.6815 mL	3.3631 mL	16.8155 mL
10 mM	0.1682 mL	0.8408 mL	1.6815 mL	8.4077 mL
20 mM	0.0841 mL	0.4204 mL	0.8408 mL	4.2039 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc