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Pyridoxine

Name: Pyridoxine
Brand: TargetMol
SKU: T0973
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0973Cas No. 65-23-6

Alias Vitamin B6, Pyridoxol, Gravidox

Pyridoxine (Vitamin B6) is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Although pyridoxine and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading.

Pyridoxine

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Purity: 99.83%

Catalog No. T0973Alias Vitamin B6, Pyridoxol, GravidoxCas No. 65-23-6

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$39	In Stock	In Stock
500 mg	$91	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Pyridoxine AI Summary

Pyridoxine exhibits diverse bioactivities across multiple biological systems and assays. It shows promising bioactivity in reducing collagen-induced platelet aggregation at a concentration of 0.5 mM, reducing aggregation by 4.0% at both 5 µg/mL and 1 µg/mL concentrations, although it is ineffective at reducing ADP or thrombin receptor activating peptide-induced aggregation. In bone infection patients, Pyridoxine inhibits linezolid-induced hematological events, with a 45.8% inhibition of thrombocytopenia and a 25.0% inhibition of anemia at a concentration of 125 mg. The compound displays activity at human PKH kinase with a Km value of 9900 nM and exhibits potency against HSD17B4, JMJD2E, ALDH1A1, and HPGD, with IC50 values ranging from 12,589.3 nM to 28,183.8 nM. Additionally, it shows anti-viral activity by blocking Marburg and Ebola viruses' entry, with AC50 values between 6.31 µM and 28,183.8 nM. Pyridoxine does not induce drug-induced liver injury, based on validation datasets. Its effect includes stimulating systemic acquired resistance against Sclerospora graminicola in Cenchrus americanus and promoting seed germination, especially when seeds are treated with 20 mM of the compound. The compound demonstrates moderate liver toxicity marked by elevated serum ALT, AST, and alkaline phosphatase levels but does not significantly induce other liver toxicities. It also shows limited distribution preferences with a LogD7.4 value of -0.58 and minimal inhibitory activity against human BSEP, with an IC50 over 1000000 nM. Despite an observed free maximum concentration of 0.122 µM in human plasma and weak inhibition of HDAC6, Pyridoxine exhibits weak antiviral activity against SARS-CoV-2 with IC50 values exceeding 20000 nM. Pharmacokinetic assessments reveal a Cmax of 60 nM when administered orally at 4 mg, with Tmax at 1.0 hr, and urinary excretion peaks at 3 hrs with 0.7 µmol/hr. Despite its binding to several human receptors and enzymes, the compound remains largely inactive with AC50 values over 30000 nM across several targets..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pyridoxine (Vitamin B6) is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Although pyridoxine and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading.
Synonyms	Vitamin B6, Pyridoxol, Gravidox

Chemical Properties

Molecular Weight	169.18
Formula	C₈H₁₁NO₃
Cas No.	65-23-6
Smiles	CC1=C(O)C(CO)=C(CO)C=N1
Relative Density.	1.2435 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 127 mg/mL (750.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (23.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.9109 mL	29.5543 mL	59.1086 mL	295.5432 mL
5 mM	1.1822 mL	5.9109 mL	11.8217 mL	59.1086 mL
10 mM	0.5911 mL	2.9554 mL	5.9109 mL	29.5543 mL
20 mM	0.2955 mL	1.4777 mL	2.9554 mL	14.7772 mL
50 mM	0.1182 mL	0.5911 mL	1.1822 mL	5.9109 mL
100 mM	0.0591 mL	0.2955 mL	0.5911 mL	2.9554 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc