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Vanin-1-IN-1

Name: Vanin-1-IN-1
Brand: TargetMol
SKU: T8218
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8218Cas No. 2173134-00-2

Alias VUN34002

Vanin-1-IN-1 (VUN34002) is an vanin-1 enzyme inhibitor.

Vanin-1-IN-1

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Purity: 99.77%

Catalog No. T8218Alias VUN34002Cas No. 2173134-00-2

Vanin-1-IN-1 (VUN34002) is an vanin-1 enzyme inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$48	In Stock	In Stock
10 mg	$78	In Stock	In Stock
25 mg	$142	In Stock	In Stock
50 mg	$207	In Stock	In Stock
100 mg	$328	In Stock	In Stock
200 mg	$492	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.77%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Vanin-1-IN-1 AI Summary

Vanin-1-IN-1 demonstrates significant inhibitory activity in vanin-1 assays across human, mouse, and rat plasma, with IC50 values ranging from 6.85 nM to 53.4 nM. It also shows an IC50 value below 50000.0 nM in the biotinidase assay. Notably, this compound exhibits high plasma protein binding in humans (Fu = 0.812) and excellent oral bioavailability in rats (F = 96.0% at 10 mg/kg). It strongly inhibits recombinant N-terminal human vanin-1 (IC50 = 6.85 nM) and mouse vanin-1 (IC50 = 24.5 nM), as well as human plasma vanin-1 (IC50 = 9.0 nM). In beagle dogs, it shows potent vanin-1 inhibition (IC50 = 0.9 nM). Vanin-1-IN-1 is significantly soluble in phosphate buffer at pH 7.4 (8100.0 ug/mL) and exhibits negligible inhibition on various CYP enzymes (CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP2A4). Its renal clearance is moderate in both rats and beagle dogs (CL = 55.0% and 22.0%, respectively), with a limited half-life (T1/2 = 1.0 hr in rats and 3.4 hr in beagle dogs). Additionally, it shows low unbound drug concentrations in the serum of DSS-induced mouse colitis models at various doses (ranging from 1.0 nM to 773.0 nM)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Vanin-1-IN-1 (VUN34002) is an vanin-1 enzyme inhibitor.
Synonyms	VUN34002

Chemical Properties

Molecular Weight	354.41
Formula	C₁₈H₂₂N₆O₂
Cas No.	2173134-00-2
Smiles	O=C(N1CCC2(C1)CCOCC2)c1cnc(NCc2cnccn2)nc1
Relative Density.	1.34 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (352.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (9.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8216 mL	14.1080 mL	28.2159 mL	141.0795 mL
5 mM	0.5643 mL	2.8216 mL	5.6432 mL	28.2159 mL
10 mM	0.2822 mL	1.4108 mL	2.8216 mL	14.1080 mL
20 mM	0.1411 mL	0.7054 mL	1.4108 mL	7.0540 mL
50 mM	0.0564 mL	0.2822 mL	0.5643 mL	2.8216 mL
100 mM	0.0282 mL	0.1411 mL	0.2822 mL	1.4108 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc