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Rhoifolin
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Catalog No. T2755Cas No. 17306-46-6
Alias Rhoifoloside, Apigenin-7-O-rhamnoglucoside, Apigenin 7-O-neohesperidoside
Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.
Rhoifolin
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Purity: 98.58%
Catalog No. T2755Alias Rhoifoloside, Apigenin-7-O-rhamnoglucoside, Apigenin 7-O-neohesperidosideCas No. 17306-46-6
Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $40 | In Stock | In Stock | |
| 10 mg | $73 | In Stock | In Stock | |
| 25 mg | $135 | In Stock | In Stock | |
| 50 mg | $198 | In Stock | In Stock | |
| 100 mg | $292 | - | In Stock | |
| 200 mg | $433 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $51 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.58%
Color:White to Yellow
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Product Introduction
Rhoifolin AI Summary
Rhoifolin exhibits notable antioxidant and inhibitory activities across various biological systems. It inhibits superoxide production using the xanthine/xanthine oxidase method with an IC25 of 7.2 µM and also demonstrates antioxidant activity in BALB/c mouse BM cells by inhibiting ROS production with an IC25 of 201.0 µM. It shows potential as an oxidative inhibitor in cow milk xanthine oxidase at 50 µg/mL with 12.9% inhibition and inhibits COX2 with 20.0% inhibition at 2.5 µg/mL. Additionally, it inhibits AAPH-induced hemolysis in rat red blood cells with an IC50 of 95900.0 nM and exhibits growth inhibitory activity in various human tumor cell lines with a GI50 value of 100,000.0 nM. Rhoifolin demonstrates inhibitory effects on electric eel AChE (27.23% inhibition at 2 mg/mL) and a slight decrease in inhibition on horse BChE. It has a log P value of 0.71 and a high aqueous solubility of 114.0 µg/mL. The compound significantly inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells by 101.68% and 203.09% respectively at 10 µM. Moreover, it displays antiviral activity, inhibiting the SARS-CoV 3C-like protease and SARS-CoV-2 3CL protease with IC50 values of 27400.0 nM and 27000.0 nM respectively, as determined by FRET assays..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves. |
| Synonyms | Rhoifoloside, Apigenin-7-O-rhamnoglucoside, Apigenin 7-O-neohesperidoside |
| Molecular Weight | 578.52 |
| Formula | C27H30O14 |
| Cas No. | 17306-46-6 |
| Smiles | C[C@@H]1O[C@@H](O[C@H]2[C@H](Oc3cc(O)c4c(c3)oc(cc4=O)-c3ccc(O)cc3)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O |
| Relative Density. | 1.69g/cm3 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (95.07 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.46 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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