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Tenovin-1

Name: Tenovin-1
Brand: TargetMol
SKU: T1919
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1919Cas No. 380315-80-0

Alias Tenovin 1

Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.

Tenovin-1

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Purity: 99.33%

Catalog No. T1919Alias Tenovin 1Cas No. 380315-80-0

Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.

Pack Size	Price	Availability
10 mg	$50	In Stock
25 mg	$76	In Stock
50 mg	$112	In Stock
100 mg	$202	In Stock
1 mL x 10 mM (in DMSO)	$36	In Stock

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Purity:99.33%

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COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
In vitro	Tenovin-1 (10 μM) protected p53 from mdm 2-mediated degradation, but had little effect on p53 protein synthesis. When applied to p53-expressing tumor cells, Tenovin-1 inhibited cell growth and induced apoptosis.Tenovin-1 is a p53 activator and increased the amount of p53 protein within 2 h of treatment.Tenovin-1 did not affect p53 mRNA levels.
In vivo	Tenovin-1 (10 μM) protected p53 from mdm 2-mediated degradation, but had little effect on p53 protein synthesis. When applied to p53-expressing tumor cells, Tenovin-1 inhibited cell growth and induced apoptosis.Tenovin-1 is a p53 activator and increased the amount of p53 protein within 2 h of treatment.Tenovin-1 did not affect p53 mRNA levels.
Cell Research	Cell viability isdetermined by trypan blue exclusion, Giemsa staining, or MTT assays.(Only for Reference)
Synonyms	Tenovin 1

Chemical Properties

Molecular Weight	369.48
Formula	C₂₀H₂₃N₃O₂S
Cas No.	380315-80-0
Smiles	CC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(cc2)C(C)(C)C)cc1
Relative Density.	1.238 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 9.2 mg/mL (24.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7065 mL	13.5325 mL	27.0651 mL	135.3253 mL
5 mM	0.5413 mL	2.7065 mL	5.4130 mL	27.0651 mL
10 mM	0.2707 mL	1.3533 mL	2.7065 mL	13.5325 mL
20 mM	0.1353 mL	0.6766 mL	1.3533 mL	6.7663 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc