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TUG-499

Catalog No. T60184 CAS 1206629-08-4

TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptors FFA2, FFA3 and the nuclear receptor PPARγ, as well as other different receptors, ion channels and transporter proteins.TUG-499 can be used to study type 2 Type 2 diabetes.

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TUG-499, CAS 1206629-08-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 61.00
5 mg	In stock	$ 136.00
10 mg	In stock	$ 198.00
25 mg	In stock	$ 327.00
50 mg	In stock	$ 393.00
100 mg	In stock	$ 585.00
500 mg	In stock	$ 1,270.00
1 mL * 10 mM (in DMSO)	In stock	$ 139.00

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Purity: 99.59%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptors FFA2, FFA3 and the nuclear receptor PPARγ, as well as other different receptors, ion channels and transporter proteins.TUG-499 can be used to study type 2 Type 2 diabetes.
Targets&IC50	FFAR1/GPR40:7.39(pEC50)
In vitro	TUG-499 exhibits remarkable chemical stability, does not inhibit specific CYP enzymes or P-glycoprotein, and displays outstanding Caco-2 permeability. Its potent effects are observed on recombinant human FFA1 receptors as well as the INS-1E rat insulinoma cell line.[1]

Molecular Weight	320.17
Formula	C16H11Cl2NO2
CAS No.	1206629-08-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (70.28 mM)

References and Literature

1. Christiansen E, et al. Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties. J Med Chem. 2011;54(19):6691-6703.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library GPCR Compound Library Nuclear Receptor Compound Library Bioactive Compounds Library Max Bioactive Compound Library DNA Damage & Repair Compound Library Anti-Obesity Compound Library

Related Products

Related compounds with same targets

AM-1638 JNJ-63533054 GSK137647A Vincamine P2Y2R/GPR17 antagonist 1 TUG-469 Bimatoprost acid GPR40 Agonist 2

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TUG-499 1206629-08-4 DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Metabolism PPAR GPR TUG 499 TUG499 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.