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Anti-NLRP3 Polyclonal Antibody 3 (Synonyms: PYRIN-containing APAF1-like protein 1, Pypaf1, Nlrp3, Nalp3, NAC...)
Catalog No. TMAB-01245 Copy Product Info
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Anti-NLRP3 Polyclonal Antibody 3 is a Rabbit antibody targeting NLRP3. Anti-NLRP3 Polyclonal Antibody 3 can be used in WB.
Anti-NLRP3 Polyclonal Antibody 3
Copy Product Info🥰Excellent
Catalog No. TMAB-01245
Synonyms PYRIN-containing APAF1-like protein 1, Pypaf1, Nlrp3, Nalp3, NACHT, LRR and PYD domains-containing protein 3, Mmig1, Mast cell maturation-associated-inducible protein 1, LRR and PYD domains-containing protein 3, Cryopyrin, Cold autoinflammatory syndrome 1 protein homolog, Cias1
Anti-NLRP3 Polyclonal Antibody 3 is a Rabbit antibody targeting NLRP3. Anti-NLRP3 Polyclonal Antibody 3 can be used in WB.
Anti-NLRP3 Polyclonal Antibody 3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-NLRP3 Polyclonal Antibody 3 is a Rabbit antibody targeting NLRP3. Anti-NLRP3 Polyclonal Antibody 3 can be used in WB. |
| Synonyms | PYRIN-containing APAF1-like protein 1, Pypaf1, Nlrp3, Nalp3, NACHT, LRR and PYD domains-containing protein 3, Mmig1, Mast cell maturation-associated-inducible protein 1, LRR and PYD domains-containing protein 3, Cryopyrin, Cold autoinflammatory syndrome 1 protein homolog, Cias1 |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat) |
| Verified Activity | Sample: Lane 1: LympHnode (Mouse) Lysate at 40 μg Lane 2: Lung (Mouse) Lysate at 40 μg Lane 3: Spleen (Mouse) Lysate at 40 μg Lane 4: Lung (Rat) Lysate at 40 μg Lane 5: Spleen (Rat) Lysate at 40 μg Primary: Anti-NALP3/CIAS1 (TMAB-01245) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 114-118 kDa Observed band size: 120 kDa  |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. |
| Tissue Specificity | Expressed in blood leukocytes. Strongly expressed in polymorphonuclear cells and osteoblasts. Undetectable or expressed at a lower magnitude in B- and T-lymphoblasts, respectively. High level of expression detected in chondrocytes. Detected in non-keratin |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. Subcellular Location : Cytoplasm. |
| Immunogen | KLH conjugated synthetic peptide: mouse NALP3/CIAS1 |
| Antigen Species | Mouse |
| Gene Name | NLRP3 |
| Gene ID | |
| Protein Name | NACHT, LRR and PYD domains-containing protein 3 |
| Uniprot ID | |
| Biology Area | TNF,Inflammatory mediators,Macrophage / Inflamm.,NFkB Pathway |
| Function | May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. |
| Molecular Weight | Theoretical: 114 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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