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Cortodoxone
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Catalog No. T2748Cas No. 152-58-9
Alias Reichstein's substance S, cortexolone, 17α,21-dihydroxyprogesterone, 11-Desoxycortisol, 11-Deoxycortisol
Cortodoxone (11-Desoxycortisol) is a glucocorticoid steroid hormone that is an intermediate in the biosynthesis of cortisol in the adrenal gland.
Cortodoxone
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Purity: 99.87%
Catalog No. T2748Alias Reichstein's substance S, cortexolone, 17α,21-dihydroxyprogesterone, 11-Desoxycortisol, 11-DeoxycortisolCas No. 152-58-9
Cortodoxone (11-Desoxycortisol) is a glucocorticoid steroid hormone that is an intermediate in the biosynthesis of cortisol in the adrenal gland.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $40 | In Stock | In Stock | |
| 50 mg | $61 | In Stock | In Stock | |
| 100 mg | $87 | In Stock | In Stock | |
| 500 mg | $198 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $44 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.87%
Color:White
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Product Introduction
Cortodoxone AI Summary
Cortodoxone exhibits high binding affinity towards corticosteroid-binding globulin (CBG) with a log K value of 7.881 and towards testosterone-binding globulin (TeBG) with a log K value of 7.204. It demonstrates inhibition of mouse constitutive androstane receptor (mCAR) activity with 88.0% remaining activity at 10 µM concentration. The compound shows varying binding affinities to glucocorticoid receptors in different tissues and binds to progestin, androgen, and mineralocorticoid receptors in various animal models. Additionally, Cortodoxone has multiple bioactivities including antiviral properties against SARS-CoV-2, inhibition of human HDAC6 enzyme, and potential activities against Plasmodium falciparum. The compound also demonstrates properties related to its permeability coefficient in human skin with a log Kp value of -7.7 and a bioactivity in modulating steroid binding in silico..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cortodoxone (11-Desoxycortisol) is a glucocorticoid steroid hormone that is an intermediate in the biosynthesis of cortisol in the adrenal gland. |
| Synonyms | Reichstein's substance S, cortexolone, 17α,21-dihydroxyprogesterone, 11-Desoxycortisol, 11-Deoxycortisol |
| Molecular Weight | 346.46 |
| Formula | C21H30O4 |
| Cas No. | 152-58-9 |
| Smiles | CC12CCC3C(CCC4=CC(=O)CCC34C)C1CC[C@]2(O)C(=O)CO |
| Relative Density. | 1.22g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (158.75 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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