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DXR Inhibitor 11a sodium

Name: DXR Inhibitor 11a sodium
Brand: TargetMol
SKU: T83885
Rating: 4.5 (1 reviews)

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Catalog No. T83885

Alias 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitor 11a

DXR inhibitor 11a, with an IC50 value of 0.11 µM, effectively inhibits P. falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR). It also demonstrates significant activity against P. falciparum's growth in isolated human erythrocytes, with an IC50 of 0.37 µM.

DXR Inhibitor 11a sodium

😃Good

Catalog No. T83885Alias 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitor 11a

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	Inquiry	3-6 months	3-6 months
50 mg	Inquiry	3-6 months	3-6 months
100 mg	Inquiry	3-6 months	3-6 months

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	DXR inhibitor 11a, with an IC50 value of 0.11 µM, effectively inhibits P. falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR). It also demonstrates significant activity against P. falciparum's growth in isolated human erythrocytes, with an IC50 of 0.37 µM.
Synonyms	1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitor 11a

Chemical Properties

Molecular Weight	279.20
Formula	C₁₀H₁₁NO₅P.Na
Smiles	O=C(N(O)C/C=C/P(O)([O-])=O)C1=CC=CC=C1.[Na+]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Methanol: 10 mg/mL (35.82 mM), Sonication is recommended.

Ethanol: 10 mg/mL (35.82 mM), Sonication is recommended.

Solution Preparation Table

Methanol/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.5817 mL	17.9083 mL	35.8166 mL	179.0831 mL
5 mM	0.7163 mL	3.5817 mL	7.1633 mL	35.8166 mL
10 mM	0.3582 mL	1.7908 mL	3.5817 mL	17.9083 mL
20 mM	0.1791 mL	0.8954 mL	1.7908 mL	8.9542 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc