Anti-Mouse OX40L/CD134L Antibody (RM134L)

Anti-Mouse OX40L/CD134L Antibody (RM134L) is a monoclonal antibody against mouse OX40L/CD134L that can attenuate immune responses by blocking the OX40/OX40L signaling pathway and inhibit plasma cell differentiation and antibody secretion.In addition, Anti-Mouse OX40L/CD134L Antibody (RM134L) can effectively prolong the survival time of cellular transplants by acting on CD4+ T cells.This antibody is suitable for studies related to inflammation and cancer, including graft-versus-host disease (GVHD), allergic reactions, lupus nephritis, and hepatocellular carcinoma (HCC) .

Anti-Mouse OX40L/CD134L Antibody (RM134L) (5 μg/mL) significantly inhibits the activation of CD8+ T cells by tumor-associated macrophages (TAM) [3].
Anti-Mouse OX40L/CD134L Antibody (RM134L) (1–100 μg/mL, treated for 3 days) dose-dependently inhibits Th1 and Tfh cell differentiation and promotes Treg cell differentiation [4].
Anti-Mouse OX40L/CD134L Antibody (RM134L) (1–100 μg/mL, treated for 72 hours) inhibits plasma cell differentiation and antibody secretion (IgG2b, IgG3, IgA, IgM), downregulates the expression of BLIMP1 and XBP1, and upregulates the expression of SPIB in B cells [4].

Anti-Mouse OX40L/CD134L Antibody (RM134L) (0.5 mg, intraperitoneal injection, administered on days 0, 2, 4, and 8 in the early stage, and on days 21, 23, 25, and 29 in the late stage), in combination with CD40L monoclonal antibody and CTLA4Ig, delays antibody production in female BALB/c mice in a Phl p 5-induced grass pollen allergy model [1].
Anti-Mouse OX40L/CD134L Antibody (RM134L) (200 μg, intraperitoneal injection, once daily until day 5, then three times weekly until day 28) significantly prolongs the survival time of B10.BR/SgSnJ (H2k) mice with graft-versus-host disease (GVHD) [2].
Anti-Mouse OX40L/CD134L Antibody (RM134L) (250 μg, intraperitoneal injection, every 3 days from day -2 until the experimental endpoint) markedly reverses the anti-tumor effect of C12 iE DAP in C57BL/6 mice bearing Hepa 1-6, B16F10, or MC38 tumors [3].
Anti-Mouse OX40L/CD134L Antibody (RM134L) (100 μg, intraperitoneal injection, twice weekly for 10 consecutive weeks) alleviates lupus nephritis in female MRL/Lpr mice with spontaneous lupus [4].
Anti-Mouse OX40L/CD134L Antibody (RM134L) (100 μg, intraperitoneal injection, once daily for 3 consecutive weeks) reduces the autoimmune response in female C57BL/6J mice immunized with keyhole limpet hemocyanin (KLH) [4].

RM134L

Mouse

Monoclonal

Unconjugated