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Bevirimat

Name: Bevirimat
Brand: TargetMol
SKU: T5782
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T5782Cas No. 174022-42-5

Alias YK FH312, PA-457, MPC-4326

Bevirimat (PA-457) is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during virion maturation.

Bevirimat

🥰Excellent

Purity: 99.4%

Catalog No. T5782Alias YK FH312, PA-457, MPC-4326Cas No. 174022-42-5

Bevirimat (PA-457) is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during virion maturation.

Pack Size	Price	Availability
1 mg	$47	In Stock
5 mg	$97	In Stock
10 mg	$163	In Stock
25 mg	$363	In Stock
50 mg	$538	In Stock
100 mg	$768	In Stock
1 mL x 10 mM (in DMSO)	$125	In Stock

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Batch Information

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Purity:99.4%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Bevirimat (PA-457) is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during virion maturation.
In vivo	PA-457 reduced viral load in HIV-infected adults in a dose-dependent fashion, when given in a single oral dose in a clinical study[1].
Synonyms	YK FH312, PA-457, MPC-4326

Chemical Properties

Molecular Weight	584.83
Formula	C₃₆H₅₆O₆
Cas No.	174022-42-5
Smiles	[H][C@]12[C@@H](CC[C@@]1(CC[C@]1(C)[C@]2([H])CC[C@]2([H])[C@@]3(C)CC[C@H](OC(=O)CC(C)(C)C(O)=O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O)C(C)=C
Relative Density.	1.13 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (85.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7099 mL	8.5495 mL	17.0990 mL	85.4949 mL
5 mM	0.3420 mL	1.7099 mL	3.4198 mL	17.0990 mL
10 mM	0.1710 mL	0.8549 mL	1.7099 mL	8.5495 mL
20 mM	0.0855 mL	0.4275 mL	0.8549 mL	4.2747 mL
50 mM	0.0342 mL	0.1710 mL	0.3420 mL	1.7099 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc