Z-LVG-CHN2

Name: Z-LVG-CHN2
Brand: TargetMol
SKU: T38130
Rating: 4.5 (1 reviews)

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Catalog No. T38130Cas No. 119670-30-3

Alias Z-Leu-Val-Gly-diazomethylketone

The diazomethyl ketone Z-LVG-CHN2 mimics part of the human cysteine proteinase-binding center, has been shown to be an irreversible inhibitor of this proteinase. The compound was also tested for antiviral activity against herpes simplex virus type 1 (HSV) and found to block the HSV replication. Irreversible inhibitor of streptopain.

Z-LVG-CHN2

🥰Excellent

Catalog No. T38130Alias Z-Leu-Val-Gly-diazomethylketoneCas No. 119670-30-3

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Product Introduction

Bioactivity

Description	The diazomethyl ketone Z-LVG-CHN2 mimics part of the human cysteine proteinase-binding center, has been shown to be an irreversible inhibitor of this proteinase. The compound was also tested for antiviral activity against herpes simplex virus type 1 (HSV) and found to block the HSV replication. Irreversible inhibitor of streptopain.
Targets&IC50	SAR CoV-2:190 nM (EC50)
Synonyms	Z-Leu-Val-Gly-diazomethylketone

Chemical Properties

Molecular Weight	445.52
Formula	C₂₂H₃₁N₅O₅
Cas No.	119670-30-3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Methanol: 50 mg/mL (112.23 mM), Sonication is recommended.

Solution Preparation Table

Methanol

	1mg	5mg	10mg	50mg
1 mM	2.2446 mL	11.2228 mL	22.4457 mL	112.2284 mL
5 mM	0.4489 mL	2.2446 mL	4.4891 mL	22.4457 mL
10 mM	0.2245 mL	1.1223 mL	2.2446 mL	11.2228 mL
20 mM	0.1122 mL	0.5611 mL	1.1223 mL	5.6114 mL
50 mM	0.0449 mL	0.2245 mL	0.4489 mL	2.2446 mL
100 mM	0.0224 mL	0.1122 mL	0.2245 mL	1.1223 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc