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Z-LVG-CHN2

Name: Z-LVG-CHN2
Brand: TargetMol
SKU: T38130
Rating: 4.5 (1 reviews)

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Catalog No. T38130Cas No. 119670-30-3

Alias Z-Leu-Val-Gly-diazomethylketone

The diazomethyl ketone Z-LVG-CHN2 mimics part of the human cysteine proteinase-binding center, has been shown to be an irreversible inhibitor of this proteinase. The compound was also tested for antiviral activity against herpes simplex virus type 1 (HSV) and found to block the HSV replication. Irreversible inhibitor of streptopain.

Z-LVG-CHN2

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Catalog No. T38130Alias Z-Leu-Val-Gly-diazomethylketoneCas No. 119670-30-3

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Product Introduction

Bioactivity

Description	The diazomethyl ketone Z-LVG-CHN2 mimics part of the human cysteine proteinase-binding center, has been shown to be an irreversible inhibitor of this proteinase. The compound was also tested for antiviral activity against herpes simplex virus type 1 (HSV) and found to block the HSV replication. Irreversible inhibitor of streptopain.
Targets&IC50	SAR CoV-2:190 nM (EC50)
Synonyms	Z-Leu-Val-Gly-diazomethylketone

Chemical Properties

Molecular Weight	445.52
Formula	C₂₂H₃₁N₅O₅
Cas No.	119670-30-3
Smiles	CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)C=[N+]=[N-]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Methanol: 50 mg/mL (112.23 mM), Sonication is recommended.

Solution Preparation Table

Methanol

	1mg	5mg	10mg	50mg
1 mM	2.2446 mL	11.2228 mL	22.4457 mL	112.2284 mL
5 mM	0.4489 mL	2.2446 mL	4.4891 mL	22.4457 mL
10 mM	0.2245 mL	1.1223 mL	2.2446 mL	11.2228 mL
20 mM	0.1122 mL	0.5611 mL	1.1223 mL	5.6114 mL
50 mM	0.0449 mL	0.2245 mL	0.4489 mL	2.2446 mL
100 mM	0.0224 mL	0.1122 mL	0.2245 mL	1.1223 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc