PSMA-IN-1 (compound 23) is an inhibitor of PSMA with a Ki value of 2.49 nM. It inhibits tumor growth with high selectivity and specificity in PSMA+ tumor models. Additionally, PSMA-IN-1 serves as an NIR (λEX: 620 nm; λEM: 670 nm) dye for tumor imaging. PSMA-IN-1 is utilized in prostate cancer research.

PSMA-IN-1 (0.33 mg/kg, i.v., single dose) is an NIR dye (λ EX: 620 nm; λ EM: 670 nm) used for tumor imaging, with images captured at various time points post-injection (2, 4, 8, 12, 24, and 48 h). In a BALB/C nude mouse model with 22Rv1 tumors, PSMA-IN-1 demonstrates high selectivity and specificity in inhibiting tumor growth.