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Isopropamide Iodide

Name: Isopropamide Iodide
Brand: TargetMol
SKU: T5051
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5051Cas No. 71-81-8

Isopropamide iodide is a long-acting anticholinergic drug used for peptic ulcers and other gastrointestinal disorders, and as a muscarinic receptor antagonist for diseases affecting cognition [including Alzheimer's disease].

Isopropamide Iodide

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Purity: 99.67%

Catalog No. T5051Cas No. 71-81-8

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$35	In Stock	In Stock
25 mg	$56	In Stock	In Stock
50 mg	$80	In Stock	In Stock
100 mg	$119	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.67%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Isopropamide Iodide AI Summary

Isopropamide Iodide is an active multi-target inhibitor that exhibits potency in various bioassays targeting multiple enzymes and proteins. It inhibits enzymes such as phosphofructokinase, histone lysine methyltransferase G9a, polymerase Iota, Scp-1 phosphatase, Trypanosoma brucei, human tyrosyl-DNA phosphodiesterase 1 (TDP1), and PLK1-PDB, demonstrating its potential in affecting various biological pathways and processes. Additionally, Isopropamide Iodide significantly inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells, showing high inhibitory percentages of 83.43% and 91.67%, respectively, at a concentration of 10 µM. However, it shows little to no activity in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2, with an assay result of -0.009585. Nevertheless, it exhibits antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, with inhibition rates of -11.52% and 0.08% at 10 µM after 48 hours, respectively. Lastly, Isopropamide Iodide marginally inhibits the SARS-CoV-2 3CL-Pro protease by 26.13% at a concentration of 20 µM, as determined by a FRET assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	480.43
Formula	C₂₃H₃₃IN₂O
Cas No.	71-81-8
Smiles	[I-].CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C
Relative Density.	1.2711 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 20 mg/mL (41.63 mM), Sonication is recommended.

DMSO: 60 mg/mL (124.89 mM), Sonication is recommended.

H2O: 8 mg/mL (16.65 mM), Sonication is recommended.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0815 mL	10.4073 mL	20.8147 mL	104.0734 mL
5 mM	0.4163 mL	2.0815 mL	4.1629 mL	20.8147 mL
10 mM	0.2081 mL	1.0407 mL	2.0815 mL	10.4073 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1041 mL	0.5204 mL	1.0407 mL	5.2037 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0416 mL	0.2081 mL	0.4163 mL	2.0815 mL
100 mM	0.0208 mL	0.1041 mL	0.2081 mL	1.0407 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc